umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Vacuole Integrity Maintained by DUF300 Proteins Is Required for Brassinosteroid Signaling Regulation
Umeå University, Faculty of Science and Technology, Umeå Plant Science Centre (UPSC). Institute of Biochemistry and Biology, Plant Physiology, University of Potsdam, 14476 Potsdam, Germany.
Show others and affiliations
2018 (English)In: Molecular Plant, ISSN 1674-2052, E-ISSN 1752-9867, Vol. 11, no 4, p. 553-567Article in journal (Refereed) Published
Abstract [en]

Brassinosteroid (BR) hormone signaling controls multiple processes during plant growth and development and is initiated at the plasma membrane through the receptor kinase BRASSINOSTEROID INSENSITIVE1 (BRI1) together with co-receptors such as BRI1-ASSOCIATED RECEPTOR KINASE1 (BAK1). BRI1 abundance is regulated by endosomal recycling and vacuolar targeting, but the role of vacuole-related proteins in BR receptor dynamics and BR responses remains elusive. Here, we show that the absence of two DUF300 domain-containing tonoplast proteins, LAZARUS1 (LAZ1) and LAZ1 HOMOLOG1 (LAZ1H1), causes vacuole morphology defects, growth inhibition, and constitutive activation of BR signaling. Intriguingly, tonoplast accumulation of BAK1 was substantially increased and appeared causally linked to enhanced BRI1 trafficking and degradation in laz1 laz1h1 plants. Since unrelated vacuole mutants exhibited normal BR responses, our findings indicate that DUF300 proteins play distinct roles in the regulation of BR signaling by maintaining vacuole integrity required to balance subcellular BAK1 pools and BR receptor distribution.

Place, publisher, year, edition, pages
Cell Press , 2018. Vol. 11, no 4, p. 553-567
Keywords [en]
brassinosteroid signaling, vacuole integrity, DUF300 proteins, tonoplast, Arabidopsis
National Category
Cell Biology
Identifiers
URN: urn:nbn:se:umu:diva-148631DOI: 10.1016/j.molp.2017.12.015ISI: 000428983100006PubMedID: 29288738OAI: oai:DiVA.org:umu-148631DiVA, id: diva2:1223911
Available from: 2018-06-26 Created: 2018-06-26 Last updated: 2018-06-26Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMed

Authority records BETA

Viotti, Corrado

Search in DiVA

By author/editor
Viotti, Corrado
By organisation
Umeå Plant Science Centre (UPSC)
In the same journal
Molecular Plant
Cell Biology

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 30 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf