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Facile Chemoenzymatic Synthesis of O-Mannosyl Glycans
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2018 (English)In: Angewandte Chemie International Edition, ISSN 1433-7851, E-ISSN 1521-3773, Vol. 57, no 30, p. 9268-9273Article in journal (Refereed) Published
Abstract [en]

Abstract O?Mannosylation is a vital protein modification involved in brain and muscle development whereas the biological relevance of O-mannosyl glycans has remained largely unknown owing to the lack of structurally defined glycoforms. An efficient scaffold synthesis/enzymatic extension (SSEE) strategy was developed to prepare such structures by combining gram-scale convergent chemical syntheses of three scaffolds and strictly controlled sequential enzymatic extension catalyzed by glycosyltransferases. In total, 45 O-mannosyl glycans were obtained, covering the majority of identified mammalian structures. Subsequent glycan microarray analysis revealed fine specificities of glycan-binding proteins and specific antisera.

Place, publisher, year, edition, pages
Wiley-VCH Verlagsgesellschaft, 2018. Vol. 57, no 30, p. 9268-9273
Keywords [en]
carbohydrates, chemoenzymatic synthesis, glycosylation, microarrays, O-mannosyl glycans
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URN: urn:nbn:se:umu:diva-150034DOI: 10.1002/anie.201803536ISI: 000438712600005OAI: oai:DiVA.org:umu-150034DiVA, id: diva2:1230633
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2018/07/04
Available from: 2018-07-04 Created: 2018-07-04 Last updated: 2018-10-29Bibliographically approved

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Ulrika, Westerlind

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