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Effective Assignment of α2,3/α2,6-Sialic Acid Isomers by LC-MS/MS-Based Glycoproteomics
Umeå University, Faculty of Science and Technology, Department of Chemistry.
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2018 (English)In: Angewandte Chemie International Edition, ISSN 1433-7851, E-ISSN 1521-3773, Vol. 57, no 30, p. 9320-9324Article in journal (Refereed) Published
Abstract [en]

Distinct structural changes of the α2,3/α2,6-sialic acid glycosidic linkages on glycoproteins are of importance in cancer biology, inflammatory diseases, and virus tropism. Current glycoproteomic methodologies are, however, not amenable toward high-throughput characterization of sialic acid isomers. To enable such assignments, a mass spectrometry method utilizing synthetic model glycopeptides for the analysis of oxonium ion intensity ratios was developed. This method was successfully applied in large-scale glycoproteomics, thus allowing the site-specific structural characterization of sialic acid isomers.

Place, publisher, year, edition, pages
Wiley-VCH Verlagsgesellschaft, 2018. Vol. 57, no 30, p. 9320-9324
Keywords [en]
glycopeptides, glycosylation, isomers, mass spectrometry, sialic acids
National Category
Analytical Chemistry
Identifiers
URN: urn:nbn:se:umu:diva-150035DOI: 10.1002/anie.201803540ISI: 000438712600015PubMedID: 29742324Scopus ID: 2-s2.0-85050031736OAI: oai:DiVA.org:umu-150035DiVA, id: diva2:1230638
Available from: 2018-07-04 Created: 2018-07-04 Last updated: 2018-10-26Bibliographically approved

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Pett, ChristianSchorlemer, ManuelWesterlind, Ulrika

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