umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Circulating isoflavone and lignan concentrations and prostate cancer risk: a meta-analysis of individual participant data from seven prospective studies including 2828 cases and 5593 controls
Show others and affiliations
2018 (English)In: International Journal of Cancer, ISSN 0020-7136, E-ISSN 1097-0215, Vol. 143, no 11, p. 2677-2686Article in journal (Refereed) Published
Abstract [en]

Phytoestrogens may influence prostate cancer development. This study aimed to examine the association between pre-diagnostic circulating concentrations of isoflavones (genistein, daidzein, equol) and lignans (enterolactone and enterodiol) and the risk of prostate cancer. Individual participant data were available from seven prospective studies (two studies from Japan with 241 cases and 503 controls and five studies from Europe with 2,828 cases and 5,593 controls). Because of the large difference in circulating isoflavone concentrations between Japan and Europe, analyses of the associations of isoflavone concentrations and prostate cancer risk were evaluated separately. Prostate cancer risk by study-specific fourths of circulating concentrations of each phytoestrogen was estimated using multivariable-adjusted conditional logistic regression. In men from Japan, those with high compared to low circulating equol concentrations had a lower risk of prostate cancer (multivariable-adjusted OR for upper quartile [Q4] vs Q1=0.61, 95% confidence interval [CI]=0.39-0.97), although there was no significant trend (OR per 75 percentile increase=0.69, 95 CI=0.46-1.05, Ptrend =0.085); Genistein and daidzein concentrations were not significantly associated with risk (ORs for Q4 vs Q1=0.70, 0.45-1.10, and 0.71, 0.45-1.12, respectively). In men from Europe, circulating concentrations of genistein, daidzein and equol were not associated with risk. Circulating lignan concentrations were not associated with the risk of prostate cancer, overall or by disease aggressiveness or time to diagnosis. There was no strong evidence that pre-diagnostic circulating concentrations of isoflavones or lignans are associated with prostate cancer risk, although further research is warranted in populations where isoflavone intakes are high.

Place, publisher, year, edition, pages
John Wiley & Sons, 2018. Vol. 143, no 11, p. 2677-2686
Keywords [en]
isoflavones, lignans, phytoestrogens, pooled analysis, prostate cancer risk
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:umu:diva-150143DOI: 10.1002/ijc.31640ISI: 000450846900006PubMedID: 29971774Scopus ID: 2-s2.0-85054090054OAI: oai:DiVA.org:umu-150143DiVA, id: diva2:1232185
Funder
Swedish Cancer SocietyAvailable from: 2018-07-10 Created: 2018-07-10 Last updated: 2018-12-19Bibliographically approved

Open Access in DiVA

fulltext(942 kB)44 downloads
File information
File name FULLTEXT02.pdfFile size 942 kBChecksum SHA-512
2eab52dad6c8ae3d21f1520fe58bb4027583191d0ce1090dffaae53b87748a3fc0c47b5d8aba02564e6adb9ce9d3f5732e536fd54dba914c7ebcd2c1009f0825
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMedScopus

Authority records BETA

Johansson, AndersLandberg, RikardNilsson, Lena Maria

Search in DiVA

By author/editor
Johansson, AndersLandberg, RikardNilsson, Lena Maria
By organisation
Department of OdontologyNutritional ResearchArctic Research Centre at Umeå University
In the same journal
International Journal of Cancer
Cancer and Oncology

Search outside of DiVA

GoogleGoogle Scholar
Total: 54 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 103 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf