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Survivin improves the early recognition of rheumatoid arthritis among patients with arthralgia: A population-based study within two university cities of Sweden
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Rheumatology.
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2018 (English)In: Seminars in Arthritis & Rheumatism, ISSN 0049-0172, E-ISSN 1532-866X, Vol. 47, no 6, p. 778-785Article, review/survey (Refereed) Published
Abstract [en]

Objectives: The aim of this study was to validate the use of survivin for preclinical recognition of rheumatoid arthritis (RA) among patients with unexplained arthralgia.

Methods: Serum levels of survivin and the arthritis-specific autoantibodies RF and ACPA were measured in total of 5046 patients with musculoskeletal complains during 12 consecutive months in Gothenburg and in Umea. Among them, 303 arthralgia patients were identified and prospectively followed.

Results: After 48 months, 12.2% of the arthralgia patients developed RA. Most of RA cases had high serum survivin, which increased the relative risk for RA (RR = 5.90,p = 3 x 10(-7)). Combination of survivin with autoantibodies was present in only 4.6% of the arthralgia patients and increased further the risk of RA and shortened time to RA development. Presence of any single autoantibody in the survivin-negative patients was associated with a minor risk for RA and had RA-free survival similar to the reference group.

Conclusion: This study shows that measurement of survivin in serum improves estimation of RA risk and prospectively predicts RA development in patients with arthralgia. Survivin may indicate a phase preceding autoantibody production. 

Place, publisher, year, edition, pages
Saunders Elsevier, 2018. Vol. 47, no 6, p. 778-785
Keywords [en]
Rheumatoid arthritis, Arthralgia, Survivin, Population-based study, Disease prediction, Auto- tibodies
National Category
Rheumatology and Autoimmunity
Identifiers
URN: urn:nbn:se:umu:diva-150185DOI: 10.1016/j.semarthrit.2017.10.020ISI: 000434493800003PubMedID: 29174794OAI: oai:DiVA.org:umu-150185DiVA, id: diva2:1233542
Funder
Swedish Research Council, 521:2011-2414Swedish Research Council, 521: 2014-2637Swedish Research Council, 2012-4096Swedish Rheumatism Association, R-566961Swedish Rheumatism Association, R-477321Swedish Rheumatism Association, R-478421Swedish Rheumatism Association, R-663511King Gustaf V Jubilee FundSwedish Society of MedicineTorsten Söderbergs stiftelseRegion Västra GötalandAvailable from: 2018-07-18 Created: 2018-07-18 Last updated: 2018-07-18Bibliographically approved

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Siljehult, FilipEriksson, CatharinaRantapää-Dahlqvist, Solbritt

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