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Long non-coding RNA and Polycomb: an intricate partnership in cancer biology
Umeå University, Faculty of Medicine, Wallenberg Centre for Molecular Medicine at Umeå University (WCMM). Umeå University, Faculty of Medicine, Department of Medical Biosciences, Pathology.
Umeå University, Faculty of Medicine, Wallenberg Centre for Molecular Medicine at Umeå University (WCMM). Umeå University, Faculty of Medicine, Department of Medical Biosciences, Pathology.
2018 (English)In: Frontiers in Bioscience, ISSN 1093-9946, E-ISSN 1093-4715, Vol. 23, p. 2106-2132Article in journal (Refereed) Published
Abstract [en]

High-throughput analyses have revealed that the vast majority of the transcriptome does not code for proteins. These non-translated transcripts, when larger than 200 nucleotides, are termed long non-coding RNAs (lncRNAs), and play fundamental roles in diverse cellular processes. LncRNAs are subject to dynamic chemical modification, adding another layer of complexity to our understanding of the potential roles that lncRNAs play in health and disease. Many lncRNAs regulate transcriptional programs by influencing the epigenetic state through direct interactions with chromatin-modifying proteins. Among these proteins, Polycomb repressive complexes 1 and 2 (PRC1 and PRC2) have been shown to be recruited by lncRNAs to silence target genes. Aberrant expression, deficiency or mutation of both lncRNA and Polycomb have been associated with numerous human diseases, including cancer. In this review, we have highlighted recent findings regarding the concerted mechanism of action of Polycomb group proteins (PcG), acting together with some classically defined lncRNAs including X-inactive specific transcript (XIST), antisense non-coding RNA in the INK4 locus (ANRIL), metastasis associated lung adenocarcinoma transcript 1 (MALAT1), and HOX transcript antisense RNA (HOTAIR).

Place, publisher, year, edition, pages
2018. Vol. 23, p. 2106-2132
Keywords [en]
cancer, lncRNA, Polycomb, XIST, ANRIL, HOTAIR, MALAT1, RNA modification, Review
National Category
Medical Genetics Cell and Molecular Biology
Identifiers
URN: urn:nbn:se:umu:diva-150389DOI: 10.2741/4693ISI: 000439047100010PubMedID: 29772549OAI: oai:DiVA.org:umu-150389DiVA, id: diva2:1236900
Available from: 2018-08-06 Created: 2018-08-06 Last updated: 2019-05-10Bibliographically approved

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Achour, CyrinneAguilo, Francesca

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