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Wide-field corneal subbasal nerve plexus mosaics in age-controlled healthy and type 2 diabetes populations
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2018 (English)In: Scientific Data, E-ISSN 2052-4463, Vol. 5, article id 180075Article in journal (Refereed) Published
Abstract [en]

A dense nerve plexus in the clear outer window of the eye, the cornea, can be imaged in vivo to enable non-invasive monitoring of peripheral nerve degeneration in diabetes. However, a limited field of view of corneal nerves, operator-dependent image quality, and subjective image sampling methods have led to difficulty in establishing robust diagnostic measures relating to the progression of diabetes and its complications. Here, we use machine-based algorithms to provide wide-area mosaics of the cornea's subbasal nerve plexus (SBP) also accounting for depth (axial) fluctuation of the plexus. Degradation of the SBP with age has been mitigated as a confounding factor by providing a dataset comprising healthy and type 2 diabetes subjects of the same age. To maximize reuse, the dataset includes bilateral eye data, associated clinical parameters, and machine-generated SBP nerve density values obtained through automatic segmentation and nerve tracing algorithms. The dataset can be used to examine nerve degradation patterns to develop tools to non-invasively monitor diabetes progression while avoiding narrow-field imaging and image selection biases.

Place, publisher, year, edition, pages
NATURE PUBLISHING GROUP , 2018. Vol. 5, article id 180075
National Category
Endocrinology and Diabetes
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URN: urn:nbn:se:umu:diva-150720DOI: 10.1038/sdata.2018.75ISI: 000430690900003PubMedID: 29688226Scopus ID: 2-s2.0-85045880797OAI: oai:DiVA.org:umu-150720DiVA, id: diva2:1239241
Available from: 2018-08-16 Created: 2018-08-16 Last updated: 2018-08-16Bibliographically approved

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Rolandsson, Olov

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