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Viremia preceding multiple sclerosis: Two nested case-control studies
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2018 (English)In: Virology, ISSN 0042-6822, E-ISSN 1096-0341, Vol. 520, p. 21-29Article in journal (Refereed) Published
Abstract [en]

Infections have been suggested to be involved in Multiple Sclerosis (MS). We used metagenomic sequencing to detect both known and yet unknown microorganisms in 2 nested case control studies of MS. Two different cohorts were followed for MS using registry linkages. Serum samples taken before diagnosis as well as samples from matched control subjects were selected.

In cohort1 with 75 cases and 75 controls, most viral reads were Anelloviridae-related and >95% detected among the cases. Among samples taken up to 2 years before MS diagnosis, Anellovirus species TTMV1, TTMV6 and TTV27 were significantly more common among cases. In cohort2, 93 cases and 93 controls were tested under the pre-specified hypothesis that the same association would be found. Although most viral reads were again related to Anelloviridae, no significant case-control differences were seen. We conclude that the Anelloviridae-MS association may be due to multiple hypothesis testing, but other explanations are possible.

Place, publisher, year, edition, pages
Elsevier, 2018. Vol. 520, p. 21-29
Keywords [en]
Multiple sclerosis, Anelloviridae, Metagenomic sequencing, Serum
National Category
Infectious Medicine
Identifiers
URN: urn:nbn:se:umu:diva-150753DOI: 10.1016/j.virol.2018.04.006ISI: 000436898700003PubMedID: 29772404Scopus ID: 2-s2.0-85047056591OAI: oai:DiVA.org:umu-150753DiVA, id: diva2:1239406
Available from: 2018-08-16 Created: 2018-08-16 Last updated: 2018-08-16Bibliographically approved

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Sundström, Peter

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