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Novel activities of safe-in-human broad-spectrum antiviral agents
Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Virology.
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2018 (English)In: Antiviral Research, ISSN 0166-3542, E-ISSN 1872-9096, Vol. 154, p. 174-182Article in journal (Refereed) Published
Abstract [en]

According to the WHO, there is an urgent need for better control of viral diseases. Re-positioning existing safe-inhuman antiviral agents from one viral disease to another could play a pivotal role in this process. Here, we reviewed all approved, investigational and experimental antiviral agents, which are safe in man, and identified 59 compounds that target at least three viral diseases. We tested 55 of these compounds against eight different RNA and DNA viruses. We found novel activities for dalbavancin against echovirus 1, ezetimibe against human immunodeficiency virus 1 and Zika virus, as well as azacitidine, cyclosporine, minocycline, oritavancin and ritonavir against Rift valley fever virus. Thus, the spectrum of antiviral activities of existing antiviral agents could be expanded towards other viral diseases.

Place, publisher, year, edition, pages
Elsevier, 2018. Vol. 154, p. 174-182
National Category
Microbiology in the medical area
Identifiers
URN: urn:nbn:se:umu:diva-150889DOI: 10.1016/j.antiviral.2018.04.016ISI: 000433651300021PubMedID: 29698664Scopus ID: 2-s2.0-85046170096OAI: oai:DiVA.org:umu-150889DiVA, id: diva2:1239783
Available from: 2018-08-17 Created: 2018-08-17 Last updated: 2018-08-17Bibliographically approved

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Strand, MårtenEvander, Magnus

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