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A mechanism for preventing asymmetric histone segregation onto replicating DNA strands
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2018 (English)In: Science, ISSN 0036-8075, E-ISSN 1095-9203, Vol. 361, no 6409, p. 1386-+-, article id eaat8849Article in journal (Refereed) Published
Abstract [en]

How parental histone (H3-H4)2 tetramers, the primary carriers of epigenetic modifications, are transferred onto leading and lagging strands of DNA replication forks for epigenetic inheritance remains elusive. Here we show that parental (H3-H4)2 tetramers are assembled into nucleosomes onto both leading and lagging strands, with a slight preference for lagging strands. The lagging strand preference increases markedly in cells lacking Dpb3 and Dpb4, two subunits of the leading strand DNA polymerase, Pol ε, due to the impairment of parental (H3-H4)2 transfer to leading strands. Dpb3-Dpb4 binds H3-H4 in vitro and participates in the inheritance of heterochromatin. These results indicate that different proteins facilitate the transfer of parental (H3-H4)2 onto leading vs lagging strands, and that Dbp3-Dpb4 plays a significant role in this poorly understood process.

Place, publisher, year, edition, pages
American Association for the Advancement of Science , 2018. Vol. 361, no 6409, p. 1386-+-, article id eaat8849
National Category
Cell and Molecular Biology
Identifiers
URN: urn:nbn:se:umu:diva-150963DOI: 10.1126/science.aat8849ISI: 000446142200050PubMedID: 30115745OAI: oai:DiVA.org:umu-150963DiVA, id: diva2:1240374
Funder
NIH (National Institute of Health), R35GM118015Swedish Cancer SocietySwedish Research Council
Note

Special Issue: SI

Available from: 2018-08-21 Created: 2018-08-21 Last updated: 2018-10-31Bibliographically approved

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Sharma, SushmaJohansson, ErikChabes, Andrei

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CiteExportLink to record
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  • apa
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