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Role of BASIC PENTACYSTEINE transcription factors in a subset of cytokinin signaling responses
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2018 (English)In: The Plant Journal, ISSN 0960-7412, E-ISSN 1365-313X, Vol. 95, no 3, p. 458-473Article in journal (Refereed) Published
Abstract [en]

Cytokinin plays diverse roles in plant growth and development, generally acting by modulating gene transcription in target tissues. The type-B Arabidopsis response regulators (ARR) transcription factors have emerged as primary targets of cytokinin signaling and are required for essentially all cytokinin-mediated changes in gene expression. The diversity of cytokinin function is likely imparted by the activity of various transcription factors working with the type-B ARRs to alter specific sets of target genes. One potential set of co-regulators modulating the cytokinin response are the BARLEY B-RECOMBINANT/BASIC PENTACYSTEINE (BBR/BPC) family of plant-specific transcription factors. Here, we show that disruption of multiple BPCs results in reduced sensitivity to cytokinin. Further, the BPCs are necessary for the induction of a subset of genes in response to cytokinin. We identified direct invivo targets of BPC6 using ChIP-Seq and found an enrichment of promoters of genes differentially expressed in response to cytokinin. Further, a significant number of BPC6 regulated genes are also direct targets of the type-B ARRs. Potential cis-binding elements for a number of other transcription factors linked to cytokinin action are enriched in the BPC binding fragments, including those for the cytokinin response factors (CRFs). In addition, several BPCs interact with a subset of type-A ARRs. Consistent with these results, a significant number of genes whose expression is altered in bpc mutant roots are also mis-expressed in crf1,3,5,6 and type-A arr3,4,5,6,7,8,9,15 mutant roots. These results suggest that the BPCs are part of a complex network of transcription factors that are involved in the response to cytokinin.

Place, publisher, year, edition, pages
John Wiley & Sons, 2018. Vol. 95, no 3, p. 458-473
Keywords [en]
Arabidopsis thaliana, ChIP-Seq, cytokinin, phytohormones, transcription factor
National Category
Biochemistry and Molecular Biology
Identifiers
URN: urn:nbn:se:umu:diva-150658DOI: 10.1111/tpj.13962ISI: 000438224100006PubMedID: 29763523OAI: oai:DiVA.org:umu-150658DiVA, id: diva2:1242663
Available from: 2018-08-28 Created: 2018-08-28 Last updated: 2018-08-28Bibliographically approved

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Collani, SilvioSchmid, Markus

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Umeå Plant Science Centre (UPSC)Department of Plant Physiology
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