umu.sePublikationer
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
An Exercise Intervention to Unravel the Mechanisms Underlying Insulin Resistance in a Cohort of Black South African Women: Protocol for a Randomized Controlled Trial and Baseline Characteristics of Participants
Visa övriga samt affilieringar
2018 (Engelska)Ingår i: JMIR Research Protocols, ISSN 1929-0748, E-ISSN 1929-0748, Vol. 7, nr 4, artikel-id e75Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background: The pathogenesis of type 2 diabetes (T2D) in black African women is complex and differs from that in their white counterparts. However, earlier studies have been cross-sectional and provide little insight into the causal pathways. Exercise training is consistently used as a model to examine the mechanisms underlying insulin resistance and risk for T2D.

Objective: The objective of the study was to examine the mechanisms underlying the changes in insulin sensitivity and secretion in response to a 12-week exercise intervention in obese black South African (SA) women.

Methods: A total of 45 obese (body mass index, BMI: 30-40 kg/m2) black SA women were randomized into a control (n=22) or experimental (exercise; n=23) group. The exercise group completed 12 weeks of supervised combined aerobic and resistance training (40-60 min, 4 days/week), while the control group maintained their typical physical activity patterns, and both groups were requested not to change their dietary patterns. Before and following the 12-week intervention period, insulin sensitivity and secretion (frequently sampled intravenous glucose tolerance test) and its primary and secondary determinants were measured. Dietary intake, sleep quality and quantity, physical activity, and sedentary behaviors were measured every 4 weeks.

Results: The final sample included 20 exercise and 15 control participants. Baseline sociodemographics, cardiorespiratory fitness, anthropometry, cardiometabolic risk factors, physical activity, and diet did not differ between the groups (P>.05).

Conclusions: The study describes a research protocol for an exercise intervention to understand the mechanisms underlying insulin sensitivity and secretion in obese black SA women and aims to identify causal pathways underlying the high prevalence of insulin resistance and risk for T2D in black SA women, targeting specific areas for therapeutic intervention.

Ort, förlag, år, upplaga, sidor
JMIR PUBLICATIONS, INC , 2018. Vol. 7, nr 4, artikel-id e75
Nyckelord [en]
diabetes mellitus type 2, insulin resistance, body fat distribution, adipose tissue, skeletal muscle, gastrointestinal microbiome, exercise, fatty liver, inflammation, energy metabolism, cardiorespiratory fitness, lipids, metabolomics, fatty acids, diet records, mitochondria, ectopic fat
Nationell ämneskategori
Näringslära
Identifikatorer
URN: urn:nbn:se:umu:diva-151181DOI: 10.2196/resprot.9098ISI: 000433882700008PubMedID: 29669711OAI: oai:DiVA.org:umu-151181DiVA, id: diva2:1245197
Tillgänglig från: 2018-09-04 Skapad: 2018-09-04 Senast uppdaterad: 2018-09-04Bibliografiskt granskad

Open Access i DiVA

fulltext(1531 kB)75 nedladdningar
Filinformation
Filnamn FULLTEXT01.pdfFilstorlek 1531 kBChecksumma SHA-512
c8b2e734806003a5923fc66a9f8535f02b6b781d44097bc90999dbc90d0418d0e7e58f03e1e7bebd849de5077cf6e28e59f3342a72c43168c4929f68b3b1ae4e
Typ fulltextMimetyp application/pdf

Övriga länkar

Förlagets fulltextPubMed

Personposter BETA

Chorell, ElinHauksson, JonOlsson, Tommy

Sök vidare i DiVA

Av författaren/redaktören
Mendham, Amy E.Chorell, ElinHauksson, JonOlsson, Tommy
Av organisationen
MedicinInstitutionen för strålningsvetenskaper
I samma tidskrift
JMIR Research Protocols
Näringslära

Sök vidare utanför DiVA

GoogleGoogle Scholar
Totalt: 75 nedladdningar
Antalet nedladdningar är summan av nedladdningar för alla fulltexter. Det kan inkludera t.ex tidigare versioner som nu inte längre är tillgängliga.

doi
pubmed
urn-nbn

Altmetricpoäng

doi
pubmed
urn-nbn
Totalt: 127 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf