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Kallikrein-related peptidase 7 overexpression in melanoma cells modulates cell adhesion leading to a malignant phenotype
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2018 (English)In: Biological chemistry (Print), ISSN 1431-6730, E-ISSN 1437-4315, Vol. 399, no 9, p. 1099-1105Article in journal (Refereed) Published
Abstract [en]

We recently reported that human melanoma cells, but not benign melanocytes, aberrantly express kallikrein-related peptidase 7 (KLK7). Here, we show a KLK7 overexpression-mediated decrease of cell adhesion to extracellular matrix binding proteins, associated with downregulation of alpha 5/beta 1/alpha v/beta 3 integrin expression. We also report an up-regulation of MCAM/CD146 and an increase in spheroid formation of these cells. Our results demonstrate that aberrant KLK7 expression leads to a switch to a more malignant phenotype suggesting a potential role of KLK7 in melanoma invasion. Thus, KLK7 may represent a biomarker for melanoma progression and may be a potential therapeutic target for melanoma.

Place, publisher, year, edition, pages
Walter de Gruyter, 2018. Vol. 399, no 9, p. 1099-1105
Keywords [en]
E-cadherin, integrins, kallikrein-related peptidase 7, MCAM/CD146, melanoma, spheroid
National Category
Cell and Molecular Biology
Identifiers
URN: urn:nbn:se:umu:diva-151387DOI: 10.1515/hsz-2017-0339ISI: 000441526200018PubMedID: 29498930OAI: oai:DiVA.org:umu-151387DiVA, id: diva2:1245941
Available from: 2018-09-06 Created: 2018-09-06 Last updated: 2018-09-06Bibliographically approved

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Brattsand, Maria

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