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Stent thrombosis rates the first year and beyond with new- and old-generation drug-eluting stents compared to bare metal stents
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2018 (English)In: Clinical Research in Cardiology, ISSN 1861-0684, E-ISSN 1861-0692, Vol. 107, no 9, p. 816-823Article in journal (Refereed) Published
Abstract [en]

Objectives: Old-generation drug-eluting coronary stents (o-DES) have despite being safe and effective been associated with an increased propensity of late stent thrombosis (ST). We evaluated ST rates in o-DES, new-generation DES (n-DES) and bare metal stents (BMS) the first year (< 1 year) and beyond 1 year (> 1 year).

Methods: We evaluated all implantations with BMS, o-DES (Cordis Cypher, Boston Scientific Taxus Libert, and Medtronic Endeavor) and n-DES in the Swedish coronary angiography and angioplasty registry (SCAAR) between 1 January 2007 and 8 January 2014 (n = 207 291). All cases of ST (n = 2 268) until 31 December 2014 were analyzed.

Results: The overall risk of ST was lower in both n-DES and o-DES compared with BMS up to 1 year (n-DES versus BMS: adjusted risk ratio (RR) 0.48 (0.41-0.58) and o-DES versus BMS: 0.56 (0.46-0.67), both p < 0.001). From 1 year after stent implantation and onward, the risk for ST was higher in o-DES compared with BMS [adjusted RR, 1.82 (1.47-2.25], p < 0.001). N-DES were associated with similar low ST rates as BMS from 1 year and onward [adjusted RR 1.21 (0.94-1.56), p = 0.135].

Conclusion: New-generation DES were associated with lower ST rates in comparison to BMS during the first-year post-stenting. After 1 year, n-DES and BMS were associated with similar ST rates.

Trial Registration: This study was a retrospective observational study and as such did not require clinical trial database registration.

Place, publisher, year, edition, pages
Springer Berlin/Heidelberg, 2018. Vol. 107, no 9, p. 816-823
Keywords [en]
Bare metal stents, Drug-eluting stents, Stent thrombosis, Percutaneous coronary intervention
National Category
Cardiac and Cardiovascular Systems
Identifiers
URN: urn:nbn:se:umu:diva-151544DOI: 10.1007/s00392-018-1252-0ISI: 000442201300010PubMedID: 29667015OAI: oai:DiVA.org:umu-151544DiVA, id: diva2:1247109
Available from: 2018-09-11 Created: 2018-09-11 Last updated: 2018-09-11Bibliographically approved

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Nilsson, Johan

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