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Correlation of Severity of Human Tick-Borne Encephalitis Virus Disease and Pathogenicity in Mice
Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Virology. Umeå University, Faculty of Medicine, Molecular Infection Medicine Sweden (MIMS).ORCID iD: 0000-0002-6139-2461
Umeå University, Faculty of Medicine, Department of Clinical Microbiology. National Cheng Kung University, Tainan, Taiwan..
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2018 (English)In: Emerging Infectious Diseases, ISSN 1080-6040, E-ISSN 1080-6059, Vol. 24, no 9, p. 1709-1712Article in journal (Refereed) Published
Abstract [en]

We compared 2 tick-borne encephalitis virus strains isolated from 2 different foci that cause different symptoms in tick-borne encephalitis patients, from neurologic to mild gastrointestinal symptoms. We compared neuroinvasiveness, neurovirulence, and proinflammatory cytokine response in mice and found unique differences that contribute to our understanding of pathogenesis.

Place, publisher, year, edition, pages
Centers for Disease control and Prevention , 2018. Vol. 24, no 9, p. 1709-1712
National Category
Infectious Medicine
Identifiers
URN: urn:nbn:se:umu:diva-151539DOI: 10.3201/eid2409.171825ISI: 000441877400015PubMedID: 30124404OAI: oai:DiVA.org:umu-151539DiVA, id: diva2:1247119
Funder
The Kempe FoundationsThe Swedish Foundation for International Cooperation in Research and Higher Education (STINT)Available from: 2018-09-11 Created: 2018-09-11 Last updated: 2018-09-11Bibliographically approved

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Kurhade, ChaitanyaLee, Yi-PingÖverby, Anna K.

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Kurhade, ChaitanyaLee, Yi-PingÖverby, Anna K.
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CiteExportLink to record
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