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Daily intake of phthalates, MEHP, and DINCH by ingestion and inhalation
Umeå University, Faculty of Science and Technology, Department of Chemistry. Swetox, Karolinska Institute, Unit of Toxicology Sciences, Forskargatan 20, 151 36, Södertälje, Sweden.
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2018 (English)In: Chemosphere, ISSN 0045-6535, E-ISSN 1879-1298, Vol. 208, p. 40-49Article in journal (Refereed) Published
Abstract [en]

Phthalate esters, suspected endocrine disrupting chemicals, are used in a wide range of applications. Because phthalate esters are not covalently bound, they can easily leach into the indoor environment and associate to dust particles. Thus, exposure may occur through inhalation, ingestion, or contact with the skin. However, it is unclear to what degree indoor dust contributes to the daily intake of phthalate esters.

This study investigates household dust as an exposure pathway for seven phthalate esters, the monoester MEHP, and the plasticizer DINCH. Household dust collected from children's sleeping rooms and from living rooms were analysed using gas and liquid chromatography tandem mass spectrometry. To compare two exposure pathways, different dust particle sizes were generated: a respirable fraction (<5 mu m) and an ingested particle fraction in the anticipated size range of skin adherence (<75 mu m). Modelling of dust inhalation and ingestion showed that the daily intake of dust-bound phthalate esters was likely to be 2 times (inhalation) to 12 times (ingestion) higher for 21-month-old children than for adults. These children's daily uptake of phthalate esters was 40-140 times higher through ingestion than inhalation. Furthermore, dust may be an exposure pathway for phthalate esters as well as for MEHP. Therefore, phthalate monoesters could be environmental contaminants of their own and need to be considered in health risk assessments. (C) 2018 Elsevier Ltd. All rights reserved.

Place, publisher, year, edition, pages
Elsevier, 2018. Vol. 208, p. 40-49
Keywords [en]
Phthalate esters, Phthalate monoesters, Household dust, Pollution particles, Indoor pollution, Indoor environment
National Category
Environmental Sciences Occupational Health and Environmental Health
Identifiers
URN: urn:nbn:se:umu:diva-151519DOI: 10.1016/j.chemosphere.2018.05.094ISI: 000441999400005PubMedID: 29860143OAI: oai:DiVA.org:umu-151519DiVA, id: diva2:1247394
Funder
Swedish Research Council Formas, 210-2012-131Available from: 2018-09-12 Created: 2018-09-12 Last updated: 2018-09-12Bibliographically approved

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Gustafsson, Åsa

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