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Known Unknowns of Mammalian Mitochondrial DNA Maintenance
Umeå University, Faculty of Medicine, Department of Medical Biochemistry and Biophysics.
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2018 (English)In: Bioessays, ISSN 0265-9247, E-ISSN 1521-1878, Vol. 40, no 9, article id 1800102Article in journal (Refereed) Published
Abstract [en]

Mammalian mitochondrial DNA (mtDNA) replication and repair have been studied intensively for the last 50 years. Although recently advances in elucidating the molecular mechanisms of mtDNA maintenance and the proteins involved in these have been made, there are disturbing gaps between the existing theoretical models and experimental observations. Conflicting data and hypotheses exist about the role of RNA and ribonucleotides in mtDNA replication, but also about the priming of replication and the formation of pathological rearrangements. In the presented review, we have attempted to match these loose ends and draft consensus where it can be found, while identifying outstanding issues for future research.

Place, publisher, year, edition, pages
Wiley-Blackwell, 2018. Vol. 40, no 9, article id 1800102
Keywords [en]
deletions, mitochondria, mtDNA, recombination, replication priming, ribonucleotide incorporation
National Category
Biochemistry and Molecular Biology
Identifiers
URN: urn:nbn:se:umu:diva-151541DOI: 10.1002/bies.201800102ISI: 000442340600012PubMedID: 29999547OAI: oai:DiVA.org:umu-151541DiVA, id: diva2:1247401
Funder
Wallenberg FoundationsThe Kempe FoundationsAvailable from: 2018-09-12 Created: 2018-09-12 Last updated: 2018-09-12Bibliographically approved

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Forslund, JosefinWanrooij, Sjoerd

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