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S100A9-Driven Amyloid-Neuroinflammatory Cascade in Traumatic Brain Injury as a Precursor State for Alzheimer's Disease
Umeå University, Faculty of Medicine, Department of Medical Biochemistry and Biophysics.ORCID iD: 0000-0001-7505-8045
Umeå University, Faculty of Medicine, Department of Medical Biochemistry and Biophysics. Department of General Chemistry, Sumy State University, Sumy, 40000, Ukraine.ORCID iD: 0000-0002-1691-9025
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2018 (English)In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 8, article id 12836Article in journal (Refereed) Published
Abstract [en]

Pro-inflammatory and amyloidogenic S100A9 protein is an important contributor to Alzheimer's disease (AD) pathology. Traumatic brain injury (TBI) is viewed as a precursor state for AD. Here we have shown that S100A9-driven amyloid-neuroinflammatory cascade was initiated in TBI and may serve as a mechanistic link between TBI and AD. By analyzing the TBI and AD human brain tissues, we demonstrated that in post-TBI tissues S100A9, produced by neurons and microglia, becomes drastically abundant compared to A beta and contributes to both precursor-plaque formation and intracellular amyloid oligomerization. Conditions implicated in TBI, such as elevated S100A9 concentration, acidification and fever, provide strong positive feedback for S100A9 nucleation-dependent amyloid formation and delay in its proteinase clearance. Consequently, both intracellular and extracellular S100A9 oligomerization correlated with TBI secondary neuronal loss. Common morphology of TBI and AD plaques indicated their similar initiation around multiple aggregation centers. Importantly, in AD and TBI we found S100A9 plaques without A beta. S100A9 and A beta plaque pathology was significantly advanced in AD cases with TBI history at earlier age, signifying TBI as a risk factor. These new findings highlight the detrimental consequences of prolonged post-TBI neuroinflammation, which can sustain S100A9-driven amyloid-neurodegenerative cascade as a specific mechanism leading to AD development.

Place, publisher, year, edition, pages
Nature Publishing Group, 2018. Vol. 8, article id 12836
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Neurology Neurosciences
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URN: urn:nbn:se:umu:diva-151784DOI: 10.1038/s41598-018-31141-xISI: 000442870300014PubMedID: 30150640OAI: oai:DiVA.org:umu-151784DiVA, id: diva2:1248253
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Swedish InstituteAvailable from: 2018-09-14 Created: 2018-09-14 Last updated: 2018-09-14Bibliographically approved

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Wang, ChaoIashchishyn, IgorKara, JohnHorvath, IstvanMoskalenko, RomanRofougaran, RezaMorozova-Roche, Ludmilla

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Wang, ChaoIashchishyn, IgorKara, JohnHorvath, IstvanMoskalenko, RomanRofougaran, RezaMorozova-Roche, Ludmilla
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