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Growing gold nanostructures for shape-selective cellular uptake
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2018 (English)In: Nanoscale Research Letters, ISSN 1931-7573, E-ISSN 1556-276X, Vol. 13, article id 254Article in journal (Refereed) Published
Abstract [en]

With development in the synthesis of shape- and size-dependent gold (Au) nanostructures (NSs) and their applications in nanomedicine, one of the biggest challenges is to understand the interaction of these shapes with cancer cells. Herein, we study the interaction of Au NSs of five different shapes with glioblastoma-astrocytoma cells. Three different shapes (nanorods, tetrahexahedra, and bipyramids), possessing tunable optical properties, have been synthesized by a single-step seed-mediated growth approach employing binary surfactant mixtures of CTAB and a secondary surfactant By the use of two-step seed-mediated approach, we obtained new NSs, named nanomakura (Makura is a Japanese word used for pillow) which is reported for the first time here. Spherical Au nanoparticles were prepared by the Turkevich method. To study NS-cell interactions, we functionalized the NSs using thiolated PEG followed by 11-Mercaptoundecanoic acid. The influence of shape and concentration of NSs on the cytotoxicity were assessed with a LIVE/DEAD assay in glioblastoma-astrocytoma cells. Furthermore, the time-dependent uptake of nanomakura was studied with TEM. Our results indicate that unlike the other shapes studied here, the nanomakura were taken up both via receptor-mediated endocytosis and macropinocytosis. Thus, from our library of different NSs with similar surface functionality, the shape is found to be an important parameter for cellular uptake.

Place, publisher, year, edition, pages
SpringerOpen , 2018. Vol. 13, article id 254
Keywords [en]
Nanomedicine, TEM, Endocytosis, LSPR, Cytotoxicity, Drug delivery, Glioblastoma-astrocytoma
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:umu:diva-151782DOI: 10.1186/s11671-018-2662-7ISI: 000443042900001PubMedID: 30155798OAI: oai:DiVA.org:umu-151782DiVA, id: diva2:1248260
Available from: 2018-09-14 Created: 2018-09-14 Last updated: 2018-09-14Bibliographically approved

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Sandvig, Axel

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