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Bacterial Strategies to Preserve Cell Wall Integrity Against Environmental Threats
Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine). Umeå University, Faculty of Medicine, Molecular Infection Medicine Sweden (MIMS). Umeå University, Faculty of Medicine, Umeå Centre for Microbial Research (UCMR).
Umeå University, Faculty of Medicine, Molecular Infection Medicine Sweden (MIMS). Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine). Umeå University, Faculty of Medicine, Umeå Centre for Microbial Research (UCMR).
Umeå University, Faculty of Medicine, Molecular Infection Medicine Sweden (MIMS). Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine). Umeå University, Faculty of Medicine, Umeå Centre for Microbial Research (UCMR).
2018 (English)In: Frontiers in Microbiology, ISSN 1664-302X, E-ISSN 1664-302X, Vol. 9, article id 2064Article, review/survey (Refereed) Published
Abstract [en]

Bacterial cells are surrounded by an exoskeleton-like structure, the cell wall, composed primarily of the peptidoglycan (PG) sacculus. This structure is made up of glycan strands cross-linked by short peptides generating a covalent mesh that shapes bacteria and prevents their lysis due to their high internal osmotic pressure. Even though the PG is virtually universal in bacteria, there is a notable degree of diversity in its chemical structure. Modifications in both the sugars and peptides are known to be instrumental for bacteria to cope with diverse environmental challenges. In this review, we summarize and discuss the cell wall strategies to withstand biotic and abiotic environmental insults such as the effect of antibiotics targeting cell wall enzymes, predatory PG hydrolytic proteins, and PG signaling systems. Finally we will discuss the opportunities that species-specific PG variability might open to develop antimicrobial therapies.

Place, publisher, year, edition, pages
Frontiers Media S.A., 2018. Vol. 9, article id 2064
Keywords [en]
peptidoglycan, lysozyme, antibiotic resistance, innate immunity, plasticity
National Category
Microbiology in the medical area Microbiology
Identifiers
URN: urn:nbn:se:umu:diva-151777DOI: 10.3389/fmicb.2018.02064ISI: 000443238500001OAI: oai:DiVA.org:umu-151777DiVA, id: diva2:1248283
Funder
Swedish Research CouncilKnut and Alice Wallenberg FoundationThe Kempe FoundationsAvailable from: 2018-09-14 Created: 2018-09-14 Last updated: 2018-09-14Bibliographically approved

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Yadav, Akhilesh K.Espaillat, AkbarCava, Felipe

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Department of Molecular Biology (Faculty of Medicine)Molecular Infection Medicine Sweden (MIMS)Umeå Centre for Microbial Research (UCMR)
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Frontiers in Microbiology
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