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Method-of-limits: Cold and warm perception thresholds at proximal and distal body regions
Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience, Clinical Neuroscience.
Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience, Clinical Neuroscience.
2018 (English)In: Clinical neurophysiology practice, ISSN 2467-981X, Vol. 3, p. 134-140Article in journal (Refereed) Published
Abstract [en]

Objective: Thermal quantitative sensory testing with the 'Method-of-Limits' is an established rationale for detection of small nerve fiber dysfunction, but adequate reference values are crucial for such evaluations, regardless of the underlying cause. This study assessed reference data for cold- (CPT) and warm- (WPT) perception thresholds at both proximal and distal sites in eight body regions of the lower and upper extremities, all determined within the same test session for each subject.

Methods: Seventy-five healthy subjects (aged 16-72 years) were tested according to the method-of-limit for CPT and WPT at the dorsum of the foot, the medial and lateral lower leg, the ventral thigh, the thenar eminence, the radial and ulnar part of the lower arm, and the anterior deltoid part of the upper arm.

Results: Overall, thermal perception thresholds (TPT) varied with test location, but were higher in the lower than in the upper part of the body, also WPT were generally higher than CPT. TPT at the dorsum foot highly correlated with age, while inconsistent correlations were noted between TPT and age or height at other tested locations.

Conclusion: This study describes for the first time reference values at eight defined body regions, at both proximal and distal sites.

Significance: The report enables refined evaluations of general small nerve fiber function, as assessed by quantitative thermal sensory testing with the Method-of-Limits.

Place, publisher, year, edition, pages
2018. Vol. 3, p. 134-140
Keywords [en]
Cold perception thresholds, Method-of-Limits, Reference data, Small nerve fiber, Warm perception thresholds
National Category
Neurosciences
Identifiers
URN: urn:nbn:se:umu:diva-151908DOI: 10.1016/j.cnp.2018.06.004PubMedID: 30215024Scopus ID: 2-s2.0-85050128934OAI: oai:DiVA.org:umu-151908DiVA, id: diva2:1248808
Available from: 2018-09-17 Created: 2018-09-17 Last updated: 2018-10-03Bibliographically approved

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Heldestad Lilliesköld, VictoriaNordh, Erik

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