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The Role of Viperin in Antiflavivirus Responses
Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Virology. Umeå University, Faculty of Medicine, Molecular Infection Medicine Sweden (MIMS). Umeå University, Faculty of Medicine, Umeå Centre for Microbial Research (UCMR).
Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Virology. Umeå University, Faculty of Medicine, Molecular Infection Medicine Sweden (MIMS). Umeå University, Faculty of Medicine, Umeå Centre for Microbial Research (UCMR).
2018 (English)In: DNA and Cell Biology, ISSN 1044-5498, E-ISSN 1557-7430, Vol. 37, no 9, p. 725-730Article in journal (Refereed) Published
Abstract [en]

Viperin is an interferon (IFN)-stimulated gene product, which is part of the first line of the intracellular response against viral infection. It is a potent antiviral protein, strongly upregulated after IFN-stimulation and virus infection. Viperin is antivirally active against many different viruses from different families and has been shown to inhibit several flaviviruses. Flaviviruses are an important group of arthropod-borne viruses that cause millions of infections annually. In this review, we focus on the recent advances of the antiviral mechanisms of viperin against these flaviviruses, both pointing to similarities and differences between viruses within the same genera.

Place, publisher, year, edition, pages
Mary Ann Liebert, 2018. Vol. 37, no 9, p. 725-730
Keywords [en]
viperin, interferon-stimulated gene, interferon, flavivirus, antiviral response, radical SAM enzyme
National Category
Microbiology in the medical area
Identifiers
URN: urn:nbn:se:umu:diva-152264DOI: 10.1089/dna.2018.4328ISI: 000443729600001PubMedID: 30059238OAI: oai:DiVA.org:umu-152264DiVA, id: diva2:1252837
Funder
Swedish Research Council, 2017-02438Swedish Foundation for Strategic Research , FFL12-0089Available from: 2018-10-03 Created: 2018-10-03 Last updated: 2018-10-03Bibliographically approved

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Lindquist, RichardÖverby, Anna K.

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VirologyMolecular Infection Medicine Sweden (MIMS)Umeå Centre for Microbial Research (UCMR)
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