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An international survey on anti-neutrophil cytoplasmic antibodies (ANCA) testing in daily clinical practice
Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Immunology/Immunchemistry.
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2018 (English)In: Clinical Chemistry and Laboratory Medicine, ISSN 1434-6621, E-ISSN 1437-4331, Vol. 56, no 10, p. 1759-1770Article in journal (Refereed) Published
Abstract [en]

Background: Detection of anti-neutrophil cytoplasmic antibodies (ANCA) is important for the diagnosis of the ANCA-associated vasculitides (AAV). For AAV, especially ANCA directed against myeloperoxidase (MPO) and proteinase 3 (PR3) are most relevant. ANCA with less well-defined specificities may, however, also be detected in other inflammatory and non-inflammatory conditions.

Methods: A questionnaire, initiated by the European Autoimmunity Standardisation Initiative (EASI), was used to gather information on methods and testing algorithms used for ANCA in clinical laboratories of 12 European countries (EASI survey).

Results: Four hundred and twenty-nine responses were included in the EASI survey analysis which revealed differences within countries and between countries. Laboratories overall were poor in adherence to international consensus on ANCA testing. Substantial variation was observed with respect to the use of ANCA indirect immunofluorescence (IIF) in the algorithm, application of distinct methods for MPO- and PR3-ANCA, the daily availability of new ANCA results, and interpretation of test results.

Conclusions: Awareness of these differences may stimulate further harmonization and standardization of ANCA testing. This may be promoted by an update of the international ANCA consensus and the introduction of international standards.

Place, publisher, year, edition, pages
Walter de Gruyter, 2018. Vol. 56, no 10, p. 1759-1770
Keywords [en]
ANCA, myeloperoxidase, proteinase-3, testing algorithm, vasculitis
National Category
Urology and Nephrology
Identifiers
URN: urn:nbn:se:umu:diva-152246DOI: 10.1515/cclm-2017-0306ISI: 000443548000029PubMedID: 28710880OAI: oai:DiVA.org:umu-152246DiVA, id: diva2:1253315
Available from: 2018-10-04 Created: 2018-10-04 Last updated: 2018-10-04Bibliographically approved

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Eriksson, Catharina

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