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Blood flow rate of ophthalmic artery in patients with normal tension glaucoma and healthy controls
Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Oftalmiatrik.
Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Oftalmiatrik.
Umeå universitet, Medicinska fakulteten, Institutionen för strålningsvetenskaper, Radiofysik.
Umeå universitet, Medicinska fakulteten, Institutionen för strålningsvetenskaper, Radiofysik.
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2018 (Engelska)Ingår i: Investigative Ophthalmology and Visual Science, ISSN 0146-0404, E-ISSN 1552-5783, Vol. 59, nr 9Artikel i tidskrift, Meeting abstract (Övrigt vetenskapligt) Published
Abstract [en]

Purpose: To determine the blood flow rate of the ophthalmic artery (OA) in patients with Normal Tension Glaucoma (NTG) compared to age-matched healthy controls using phase-contrast magnetic resonance imaging (PCMRI).

Methods: Seventeen patients with treated NTG (11 female; mean age: 70±9 years) and 16 age-matched healthy controls (10 female; mean age: 71±9 years) underwent PCMRI using a 3-Tesla scanner as well as ophthalmological examinations including visual acuity, Goldmann Applanation Tonometry, Humphrey perimetry and fundoscopy. Ophthalmic blood flow was acquired using a 2D PCMRI sequence set to a spatial resolution of 0.35mm/pixel. Mean flow rate and cross-sectional area was calculated using Segment Software. The eye with the most severe glaucomatous damage classified by visual field index (VFI) was chosen for comparison. The primary outcome was blood flow rate of OA.

Results: The mean VFI was 41% ± 26 (mean±SD) for the worse NTG eyes. The intraocular pressure was 13.6±2.6 mmHg for NTG eyes and 13.8±2.1 mmHg for control eyes. The blood flow rate in the NTG group was 9.6±3.7 ml/min compared to 11.8±5.5 ml/min in the control group. The area was 1.7±0.3 mm2 and 2.0±0.6 mm2 respectively. No statistical significance was found between NTG and the control group regarding blood flow rate (p=0.07) or OA area (p=0.12).

Conclusions: Despite OA being an anastomosis between the intracranial and extracranial circulation, possibly generating an eye unrelated variability in blood flow, we found a trend level reduction of approximately 2 ml/min in NTG. The finding warrants blood flow rate analysis of smaller arteries specifically supplying the eye, e.g. the central retinal artery.

Ort, förlag, år, upplaga, sidor
The Association for Research in Vision and Ophthalmology , 2018. Vol. 59, nr 9
Nationell ämneskategori
Oftalmologi
Identifikatorer
URN: urn:nbn:se:umu:diva-152420ISI: 000442932805099OAI: oai:DiVA.org:umu-152420DiVA, id: diva2:1253517
Konferens
Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO), APR 29-MAY 03, 2018, Honolulu, HI
Forskningsfinansiär
Svenska Sällskapet för Medicinsk Forskning (SSMF)Sveriges läkarförbundTillgänglig från: 2018-10-05 Skapad: 2018-10-05 Senast uppdaterad: 2018-10-08Bibliografiskt granskad

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Kristiansen, MartinLinden, ChristinaQvarlander, SaraWåhlin, AndersAmbarki, KhalidHallberg, PerEklund, AndersJóhannesson, Gauti

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Kristiansen, MartinLinden, ChristinaQvarlander, SaraWåhlin, AndersAmbarki, KhalidHallberg, PerEklund, AndersJóhannesson, Gauti
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OftalmiatrikRadiofysik
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Investigative Ophthalmology and Visual Science
Oftalmologi

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