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Elevated levels of insulin-like growth factor-binding protein 1 predict outcome after acute myocardial infarction: a long-term follow-up of the glucose tolerance in patients with acute myocardial infarction (GAMI) cohort
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2018 (English)In: Diabetes & Vascular Disease Research, ISSN 1479-1641, E-ISSN 1752-8984, Vol. 15, no 5, p. 387-395Article in journal (Refereed) Published
Abstract [en]

Objective: To investigate the long-term prognostic value of insulin-like growth factor-binding protein 1 in patients with acute myocardial infarction.

Methods: Patients (n=180) with admission glucose<11mmol/L without previously known diabetes admitted for an acute myocardial infarction in 1998-2000 were followed for mortality and cardiovascular events (first of cardiovascular mortality/acute myocardial infarction/stroke/severe heart failure) until the end of 2011 (median 11.6years). Fasting levels of insulin-like growth factor-binding protein 1 at day 2 were related to outcome in Cox proportional hazard regression analyses.

Results: Median age was 64years, 69% were male and median insulin-like growth factor-binding protein 1 was 20 mu g/L. Total mortality was 34% (n=61) and 44% (n=80) experienced a cardiovascular event during a median follow-up time of 11.6years. After age adjustment, insulin-like growth factor-binding protein 1 was associated with all-cause (1.40; 1.02-1.93, p=0.039) and cancer mortality (2.09; 1.15-3.79, p=0.015) but not with cardiovascular death (p=0.29) or cardiovascular events (p=0.57). After adjustments also for previous myocardial infarction, previous heart failure and body mass index, insulin-like growth factor-binding protein 1 was still associated with all-cause mortality (1.38; 1.01-1.89, p=0.046).

Conclusion: In patients with acute myocardial infarction without previously known diabetes, high insulin-like growth factor-binding protein 1 was associated with long-term all-cause and cancer mortality but not with cardiovascular events.

Place, publisher, year, edition, pages
Sage Publications, 2018. Vol. 15, no 5, p. 387-395
Keywords [en]
Acute myocardial infarction, abnormal glucose tolerance, insulin-like growth factor-binding protein 1, prognosis
National Category
Endocrinology and Diabetes Cardiac and Cardiovascular Systems
Identifiers
URN: urn:nbn:se:umu:diva-152219DOI: 10.1177/1479164118781892ISI: 000443828100003PubMedID: 29992830OAI: oai:DiVA.org:umu-152219DiVA, id: diva2:1256120
Available from: 2018-10-16 Created: 2018-10-16 Last updated: 2018-10-16Bibliographically approved

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Söderberg, Stefan

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