umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Effects of Dietary Inflammatory Index on subclinical Atherosclerosis: Population based cross-sectional study in individuals with intermediate risk of CVD in northern Sweden
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Epidemiology and Global Health.
2018 (English)Independent thesis Advanced level (degree of Master (One Year)), 10 credits / 15 HE creditsStudent thesis
Abstract [en]

Background: Dietary patterns have been shown to affect pathogenesis of different chronic diseases includingcardiovascular disease (CVD). Certain patterns of diet are believed to cause chronic low-gradeinflammation which leads to vascular changes that increase risk of CVDs. These patterns of disease arestudied by using different standardized scoring systems. Dietary inflammatory index (DII) is one of suchscoring system used to score the inflammatory potential of a diet pattern. Positive correlation ofinflammatory diet pattern with different cardiovascular problems and atherosclerosis has been wellestablished. However, studies of dietary inflammatory index on markers of subclinical atherosclerosis arescarce. This study aims to contribute to this field of study.

Methodology: We used data from the VIPVIZA study to evaluate the cross- sectional relationship between dietaryinflammatory index score (DII) and ultrasound markers of asymptomatic atherosclerosis in middle agedpopulation (aged 40-60 years) with intermediate risk of CVD (n=3064) in northern Sweden. The DIIscore was calculated using FFQ of 30 food items administered during participant’s VIP visit. CarotidUltrasound was also done at baseline VIPVIZA visit and presence and absence of plaque as well as CIMTwas studied. Statistical analysis using multiple logistic regression was conducted to look for associationbetween DII score and ultrasound results.

Results: We found no significant association for DII with subclinical atherosclerosis in univariable andmultivariable analysis. However, separate analysis for specific age groups showed that there is significantassociation in 60-year-old participants with OR 1.31(95% CI 1.02,1.68) for plaque formation but not forother outcomes. The odds of plaque formation also increased with increasing age. There was also anexpected significant association between plaque formation and other conventional CVD risk factors likemale sex (OR 1.63, 95% CI: 1.42, 1.89) and smoking (OR 1.39 95% CI: 1.24,1.57). DII score quartiles werenot significantly associated with CIMT >0.9mm and CIMT color code red in both crude and multivariablemodel analysis.

Conclusion: This study showed a mixed pattern of association between DII and subclinical atherosclerosis. The studyof inflammatory dietary pattern and its impact on pre-symptomatic vascular changes needs furtherexploration to devise dietary and behavioral recommendations as well as treatment guidelines forindividuals at risk.

Place, publisher, year, edition, pages
2018. , p. 56
Series
Centre for Public Health Report Series, ISSN 1651-341X ; 2018:13
Keywords [en]
Cardiovascular disease, CVD, Dietary inflammatory index, DII, atherosclerosis, Northern Sweden
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
URN: urn:nbn:se:umu:diva-152659OAI: oai:DiVA.org:umu-152659DiVA, id: diva2:1256534
External cooperation
Västerbottens läns landsting - Maria Wennberg; Northern Swedish Database - Ingegerd Johansson, Lena-Maria Nilsson
Educational program
Master's Programme in Public Health
Presentation
2018-05-22, Caring Science building, Room B101, Umeå University, Umeå, 14:00 (English)
Supervisors
Examiners
Available from: 2018-10-22 Created: 2018-10-17 Last updated: 2018-10-22Bibliographically approved

Open Access in DiVA

No full text in DiVA

Search in DiVA

By author/editor
Tasisa, Dame Endalew
By organisation
Epidemiology and Global Health
Public Health, Global Health, Social Medicine and Epidemiology

Search outside of DiVA

GoogleGoogle Scholar

urn-nbn

Altmetric score

urn-nbn
Total: 74 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf