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Cost-effectiveness analysis of Combination therapy for the treatment of Moderate to Severe Alzheimer’s disease in the United Kingdom: A Markov model
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Epidemiology and Global Health.
2018 (English)Independent thesis Advanced level (degree of Master (Two Years)), 10 credits / 15 HE creditsStudent thesis
Abstract [en]

Background: Alzheimer’s disease is a progressive degenerative disease of the brain resulting in dementia. The overall economic impact of dementia in the United Kingdom is 26 billion pounds a year and is expected to increase more than double in 2040.

Aim: The main aim of this study is to evaluate the cost-effectiveness of Combined therapy (Memantine+Donepezil) for the treatment of Moderate to Severe Alzheimer’s disease in the UK from a societal perspective.

Method: This Cost-effectiveness analysis was based on a Markov model. The model is simulated for 20 years using monotherapy (Memantine alone) as a comparator. Sensitivity analysis was performed for uncertainty variables.

Result: In patients with moderate-to-severe Alzheimer’s disease already receiving donepezil, treatment with memantine is proven to be cost-effective.

Conclusion: As the parameters are taken from a study conducted in a different setting hence the results should be interpreted with caution.

Place, publisher, year, edition, pages
2018. , p. 29
Series
Centre for Public Health Report Series, ISSN 1651-341X ; 2018:46
Keywords [en]
Alzheimer’s disease, Cost-effectiveness, Memantine, Donepezil, United Kingdom.
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
URN: urn:nbn:se:umu:diva-152763OAI: oai:DiVA.org:umu-152763DiVA, id: diva2:1257720
External cooperation
NICE - The Natioanl Institute for Health and Clinical Excellence - UK
Educational program
Master's Programme in Public Health
Presentation
2018-05-22, Caring Science building, Room A110, Umeå University, Umeå, 14:00 (English)
Supervisors
Examiners
Available from: 2018-10-22 Created: 2018-10-22 Last updated: 2018-10-22Bibliographically approved

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CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf