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In this article, we consider non-smooth time-dependent domains whose boundary is W^1,_p in time and single-valued, smoothly varying directions of reflection at the boundary. In this setting, we first prove existence and uniqueness of strong solutions to stochastic differential equations with oblique reflection. Secondly, we prove, using the theory of viscosity solutions, a comparison principle for fully nonlinear second-order parabolic partial differential equations with oblique derivative boundary conditions. As a consequence, we obtain uniqueness, and, by barrier construction and Perron’s method, we also conclude existence of viscosity solutions. Our results generalize two articles by Dupuis and Ishii to time-dependent domains.