umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Biomimetic oyster shell-replicated topography alters the behaviour of human skeletal stem cells
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB).
Show others and affiliations
2018 (English)In: Journal of Tissue Engineering, ISSN 2041-7314, E-ISSN 2041-7314, Vol. 9, article id 2041731418794007Article in journal (Refereed) Published
Abstract [en]

The regenerative potential of skeletal stem cells provides an attractive prospect to generate bone tissue needed for musculoskeletal reparation. A central issue remains efficacious, controlled cell differentiation strategies to aid progression of cell therapies to the clinic. The nacre surface from Pinctada maxima shells is known to enhance bone formation. However, to date, there is a paucity of information on the role of the topography of P. maxima surfaces, nacre and prism. To investigate this, nacre and prism topographical features were replicated onto polycaprolactone and skeletal stem cell behaviour on the surfaces studied. Skeletal stem cells on nacre surfaces exhibited an increase in cell area, increase in expression of osteogenic markers ALP (p<0.05) and OCN (p<0.01) and increased metabolite intensity (p<0.05), indicating a role of nacre surface to induce osteogenic differentiation, while on prism surfaces, skeletal stem cells did not show alterations in cell area or osteogenic marker expression and a decrease in metabolite intensity (p<0.05), demonstrating a distinct role for the prism surface, with the potential to maintain the skeletal stem cell phenotype.

Place, publisher, year, edition, pages
Sage Publications, 2018. Vol. 9, article id 2041731418794007
Keywords [en]
Nacre, topography, skeletal stem cell, osteogenic differentiation, bone regeneration
National Category
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy) Cell and Molecular Biology
Identifiers
URN: urn:nbn:se:umu:diva-152207DOI: 10.1177/2041731418794007ISI: 000443733700001PubMedID: 30202512OAI: oai:DiVA.org:umu-152207DiVA, id: diva2:1259916
Available from: 2018-10-31 Created: 2018-10-31 Last updated: 2018-10-31Bibliographically approved

Open Access in DiVA

fulltext(1389 kB)73 downloads
File information
File name FULLTEXT01.pdfFile size 1389 kBChecksum SHA-512
a8717ae9983f68d58893af34b2fb05ec049451366076a105c96a8b5d50947d3ea219be9062bb26ca9db4515f50b87309822472ac91fb67bbe01e0c2d15932b51
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Authority records BETA

Alakpa, Enateri V.

Search in DiVA

By author/editor
Alakpa, Enateri V.
By organisation
Department of Integrative Medical Biology (IMB)
In the same journal
Journal of Tissue Engineering
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)Cell and Molecular Biology

Search outside of DiVA

GoogleGoogle Scholar
Total: 73 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 82 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf