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Dedifferentiation of caudate functional connectivity and striatal dopamine transporter density predict memory change in normal aging
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Diagnostic Radiology. Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI).
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2018 (English)In: Proceedings of the National Academy of Sciences, Vol. 115, no 40, p. 10160-10165Article in journal (Refereed) Published
Abstract [en]

Age-related changes in striatel function are potentially important for predicting declining memory performance over the adult life span. Here, we used fMRI to measure functional connectivity of caudate subfields with large-scale association networks and positron emission tomography to measure striatal dopamine transporter (DAT) density in 51 older adults (age 65-86 years) who received annual cognitive testing for up to 7 years (mean = 5.59, range 2-7 years). Analyses showed that cortical-caudate functional connectivity was less differentiated in older compared with younger adults (n = 63, age 18-32 years). Unlike in younger adults, the central lateral caudate was less strongly coupled with the frontal parietal control network in older adults. Older adults also showed less "decoupling" of the caudate from other networks, including areas of the default network (DN) and the hippocampal complex. Contrary to expectations, less decoupling between caudate and the DN was not associated with an age-related reduction of striatal DAT, suggesting that neurobiological changes in the cortex may drive dedifferentiation of cortical-caudate connectivity. Reduction of specificity in functional coupling between caudate and regions of the DN predicted memory decline over subsequent years at older ages. The age-related reduction in striatal DAT density also predicted memory decline, suggesting that a relation between striatal functions and memory decline in aging is multifaceted. Collectively, the study provides evidence highlighting the association of age-related differences in striatal function to memory decline in normal aging.

Place, publisher, year, edition, pages
National Academy of Sciences , 2018. Vol. 115, no 40, p. 10160-10165
Keywords [en]
striatum, aging, memory, dopamine, functional connectivity
National Category
Radiology, Nuclear Medicine and Medical Imaging Geriatrics
Identifiers
URN: urn:nbn:se:umu:diva-152873DOI: 10.1073/pnas.1804641115ISI: 000446078700089PubMedID: 30224467OAI: oai:DiVA.org:umu-152873DiVA, id: diva2:1259989
Funder
NIH (National Institute of Health), S10RR023401NIH (National Institute of Health), S10RR019307NIH (National Institute of Health), S10RR019254NIH (National Institute of Health), S10RR023043Swedish Research CouncilAvailable from: 2018-10-31 Created: 2018-10-31 Last updated: 2018-10-31Bibliographically approved

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Rieckmann, Anna

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