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Impact of major neonatal morbidities on adolescents born at 23-25 weeks of gestation
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Paediatrics.
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Paediatrics. Department of Women’s and Children’s Health, Uppsala Universi ty, Uppsala, Sweden.
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Paediatrics.ORCID iD: 0000-0001-9803-6455
2018 (English)In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 107, no 11, p. 1893-1901Article in journal (Refereed) Published
Abstract [en]

Aim: More infants born extremely preterm (EPT) are surviving, but major neonatal morbidities are consistently high. This study examined the impact of bronchopulmonary dysplasia (BPD), brain injuries and severe retinopathy of prematurity (ROP) on adolescents who were born EPT.

Methods: We focused on EPT infants born at 23-25 weeks at the Swedish university hospitals in Uppsala and Umea from January 1992 to December 1998. The poor outcome data covered 140 of 142 who survived to 36 weeks, and the chronic conditions data reported by parents covered 132 of 134 still alive at 10-15 years.

Results: Of the 140 survivors at 36 weeks, 29 (21%) had poor outcomes: eight of 140 (6%) died, and 21 of 132 (16%) adolescent survivors had severe neurodevelopmental disabilities (NDD). BPD, severe ROP and/or brain injuries correlated independently with poor outcome. Of those adolescents who were free from BPD, brain injury and severe ROP, 6% had a severe NDD. The corresponding rates with any one, any two or all three neonatal morbidities were 21, 33 and 67%, respectively. BPD and brain injuries were associated with high rates of chronic conditions at 10-15 years of age resulting in functional limitations.

Conclusion: In adolescent EPT survivors, BPD and brain injuries were associated with high rates of chronic conditions and special healthcare needs.

Place, publisher, year, edition, pages
John Wiley & Sons, 2018. Vol. 107, no 11, p. 1893-1901
Keywords [en]
Chronic conditions, Extremely preterm infants, Long-term outcome, Neonatal morbidities, Neurodevelopmental outcome
National Category
Pediatrics
Identifiers
URN: urn:nbn:se:umu:diva-152972DOI: 10.1111/apa.14445ISI: 000446822800011PubMedID: 29893052OAI: oai:DiVA.org:umu-152972DiVA, id: diva2:1260257
Funder
Västerbotten County Council, ALF-VLL 67971Sven Jerring FoundationAvailable from: 2018-11-01 Created: 2018-11-01 Last updated: 2018-11-01Bibliographically approved

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Holsti, AnttiSerenius, F.Farooqi, Aijaz

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