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Ethnicity based variation in expression of E-cadherin in patients with squamous cell carcinoma of the oral tongue
Umeå University, Faculty of Medicine, Department of Medical Biosciences, Pathology. Multidisciplinary Department of Medical, Surgical and Dental Specialties, Second University of Naples; 3 Department of Neuroscience Reproductive and Dentistry Sciences, University of Naples Federico II, I-801 38 Naples, Italy.
Umeå University, Faculty of Medicine, Department of Medical Biosciences, Pathology. Umeå University, Faculty of Medicine, Department of Clinical Sciences, Otorhinolaryngology.
Umeå University, Faculty of Medicine, Department of Medical Biosciences, Pathology.
Umeå University, Faculty of Medicine, Department of Medical Biosciences, Pathology.
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2018 (English)In: Oncology Letters, ISSN 1792-1074, E-ISSN 1792-1082, Vol. 16, no 5, p. 6603-6607Article in journal (Refereed) Published
Abstract [en]

The oral tongue is the most common site for tumours within the oral cavity. Despite intense research, there has been no improvement in the survival rate for patients with oral tongue squamous cell carcinoma (OTSCC) during the last decades. Differences between oral cancer patients based on ethno-geographical distribution have been reported. The present study used immunohistochemistry to evaluate commonly used markers of cancer cell phenotypes, E-cadherin, -catenin and cytokeratins 5 and 19, in 120 patients with OTSCC. To evaluate the impact of ethnicity, patients from Sweden and Italy were included. A higher proportion of Swedish patients exhibited high expression of E-cadherin in their tumours (P=0.039), and high levels of E-cadherin in Swedish OTSCC patients that had succumbed to their disease were associated with poor prognosis. These data demonstrated differences in the pathological characteristics of OTSCC between two different European populations. The findings emphasise the need to take ethnicity/geographical location of patients into account when comparing results from different studies of OTSCC.

Place, publisher, year, edition, pages
Spandidos Publications , 2018. Vol. 16, no 5, p. 6603-6607
Keywords [en]
E-cadherin, beta catenin, squamous cell carcinoma, oral tongue, ethnicity
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:umu:diva-153550DOI: 10.3892/ol.2018.9452ISI: 000448433500141PubMedID: 30405799OAI: oai:DiVA.org:umu-153550DiVA, id: diva2:1265215
Funder
Swedish Cancer Society, 17 06 63Västerbotten County Council, MEYS-NPSI-LO1413Available from: 2018-11-22 Created: 2018-11-22 Last updated: 2019-05-10Bibliographically approved

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Sgaramella, NicolaBoldrup, LindaLoljung, LottaGu, XiaolianFåhraeus, RobinDanielsson, KarinNylander, Karin

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Sgaramella, NicolaWilms, TorbenBoldrup, LindaLoljung, LottaGu, XiaolianFåhraeus, RobinDanielsson, KarinNylander, Karin
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PathologyOtorhinolaryngologyDepartment of Odontology
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Oncology Letters
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