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Comparison of bone texture between normal individuals and patients with Kashin-Beck disease from plain radiographs in knee
Department of Medical Imaging, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China;School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, China.
Center for Machine Vision and Signal Analysis, Faculty of Information Technology and Electrical Engineering, University of Oulu, Oulu, Finland.
School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, China.
Research Unit of Medical Imaging, Physics and Technology, Faculty of Medicine, University of Oulu, Oulu, Finland; Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland; Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland.
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2018 (English)In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 8, article id 17510Article in journal (Refereed) Published
Abstract [en]

To compare tibial bone texture between Kashin-Beck disease (KBD) patients and normal individuals from plain radiographs using an advanced image analysis. Plain knee radiographs were obtained from KBD patients (n = 49) and age-matched healthy controls (n = 98). KBD were graded with diagnostic criteria WS/T 207-2010. The textural values related to bone structure from medial and lateral tibial subchondral and trabecular bones were evaluated using entropy of Laplacian-based image (ELap), entropy of local binary patterns (ELBP), homogeneity indices (HI) of local angles (HIMean, HIPerp and HIParal), and fractal dimensions from horizontal (FDHor) and vertical (FDVer) structures. KBD patients were shorter in height and lighter in weight, and their tibial width was wider than controls. Anatomical angle of KBD patients showed more genu valgus. Total KBD patients and subgroups had higher ELap, HIMean, HIPerp and HIParal in detected tibial subchondral and trabecular bones than controls, except ELap in lateral subchondral bone. ELBP, FDHor and FDVer from the detected tibial bone in KBD patients and subgroups were lower than controls, except FDVer in lateral trabecular bone. Our results indicate that micro-scale in bone texture in KBD-affected knees can be quantitatively examined from plain radiographs using an advanced image analysis.

Place, publisher, year, edition, pages
Nature Publishing Group, 2018. Vol. 8, article id 17510
Keywords [en]
Kashin-beck disease, Radiology, X-ray, bone texture
National Category
Orthopaedics Radiology, Nuclear Medicine and Medical Imaging
Research subject
Computerized Image Analysis; Orthopaedics; Radiology
Identifiers
URN: urn:nbn:se:umu:diva-153929DOI: 10.1038/s41598-018-35552-8ISI: 000451748700032PubMedID: 30504816OAI: oai:DiVA.org:umu-153929DiVA, id: diva2:1269138
Available from: 2018-12-09 Created: 2018-12-09 Last updated: 2018-12-20Bibliographically approved

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Lammi, MikkoQu, Chengjuan

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