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Effects of Aggregatibacter aphrophilus on cell cultures exposed to a well - characterized periodontal pathogen
Umeå University, Faculty of Medicine, Department of Odontology.
Umeå University, Faculty of Medicine, Department of Odontology.
2018 (English)Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
Abstract [en]

One of the most studied periodontitis causing bacterium, Aggregatibacter actinomycetemcomitans, is mostly associated with aggressive periodontal disease. Its close relative, Aggregatibacter aphrophilus, is a very similiar bacterium but seems to lack the famous virulence characteristics of its relative A. actinomycetemcomitans. Also A. aphrophilus has not been seen to participate in any oral infectious disease and has even been seen to reduce the damage done by A. actinomycetemcomitans when A. aphrophilus is present together with A. actinomycetemcomitans, compared to when A. actinomycetemcomitans is present alone. The study was made to see if A. aphrophilus really could reduce the toxicity caused by A. actinomycetemcomitans. Samples from clinical isolates of A. aphrophilus and a highly leukotoxic strain of A. actinomycetemcomitans were taken from anonymous donations and incubated together with human monocytes ( THP - 1 cells ). The cytotoxic effect of A. aphrophilus alone as well as the cytotoxic effect of A. actinomycetemcomitans alone on the human monocytes were analyzed. Also the cytotoxic effect, on the human monocytes from A. aphrophilus together with A. actinomycetemcomitans was observed. As expected, A. actinomycetemcomitans was highly toxic for the human monocytes while A. aphrophilus did not show any noteworthy toxicity. In conclusion, we could not see any effect of A. aphprophilus on the cytotoxicity of A. actinomycetemcomitans in the present test model. However, there are a lot more factors that can affect the result that one has to take into consideration that cannot be reproduced in vitro.

Place, publisher, year, edition, pages
2018. , p. 15
Keywords [en]
JP2 Aggregatibacter Actinomycetemcomitans Aphrophilus Parodontit Periodontitis
National Category
Microbiology in the medical area
Identifiers
URN: urn:nbn:se:umu:diva-154102OAI: oai:DiVA.org:umu-154102DiVA, id: diva2:1269956
External cooperation
VLL
Educational program
Dentistry Programme
Supervisors
Examiners
Available from: 2018-12-18 Created: 2018-12-11 Last updated: 2018-12-18Bibliographically approved

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CiteExportLink to record
Permanent link

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Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
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  • de-DE
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  • en-US
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