umu.sePublikationer
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Visualization of asymptomatic atherosclerotic disease for optimum cardiovascular prevention (VIPVIZA): a pragmatic, open-label, randomised controlled trial
Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin.
Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Epidemiologi och global hälsa.ORCID-id: 0000-0003-0556-1483
Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Epidemiologi och global hälsa.
Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Allmänmedicin.
Visa övriga samt affilieringar
2019 (Engelska)Ingår i: The Lancet, ISSN 0140-6736, E-ISSN 1474-547X, Vol. 393, nr 10167, s. 133-142Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

BACKGROUND: Primary prevention of cardiovascular disease often fails because of poor adherence among practitioners and individuals to prevention guidelines. We aimed to investigate whether ultrasound-based pictorial information about subclinical carotid atherosclerosis, targeting both primary care physicians and individuals, improves prevention.

METHODS: Visualization of asymptomatic atherosclerotic disease for optimum cardiovascular prevention (VIPVIZA) is a pragmatic, open-label, randomised controlled trial that was integrated within the Västerbotten Intervention Programme, an ongoing population-based cardiovascular disease prevention programme in northern Sweden. Individuals aged 40, 50, or 60 years with one or more conventional risk factors were eligible to participate. Participants underwent clinical examination, blood sampling, and ultrasound assessment of carotid intima media wall thickness and plaque formation. Participants were randomly assigned 1:1 with a computer-generated randomisation list to an intervention group (pictorial representation of carotid ultrasound plus a nurse phone call to confirm understanding) or a control group (not informed). The primary outcomes, Framingham risk score (FRS) and European systematic coronary risk evaluation (SCORE), were assessed after 1 year among participants who were followed up. This study is registered with ClinicalTrials.gov, number NCT01849575.

FINDINGS: 3532 individuals were enrolled between April 29, 2013, and June 7, 2016, of which 1783 were randomly assigned to the control group and 1749 were assigned to the intervention group. 3175 participants completed the 1-year follow-up. At the 1-year follow-up, FRS and SCORE differed significantly between groups (FRS 1·07 [95% CI 0·11 to 2·03, p=0·0017] and SCORE 0·16 [0·02 to 0·30, p=0·0010]). FRS decreased from baseline to the 1-year follow-up in the intervention group and increased in the control group (-0·58 [95% CI -0·86 to -0·30] vs 0·35 [0·08 to 0·63]). SCORE increased in both groups (0·13 [95% CI 0·09 to 0·18] vs 0·27 [0·23 to 0·30]).

INTERPRETATION: This study provides evidence of the contributory role of pictorial presentation of silent atherosclerosis for prevention of cardiovascular disease. It supports further development of methods to reduce the major problem of low adherence to medication and lifestyle modification.

Ort, förlag, år, upplaga, sidor
Elsevier, 2019. Vol. 393, nr 10167, s. 133-142
Nationell ämneskategori
Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi Kardiologi
Identifikatorer
URN: urn:nbn:se:umu:diva-154318DOI: 10.1016/S0140-6736(18)32818-6ISI: 000455437100026PubMedID: 30522919OAI: oai:DiVA.org:umu-154318DiVA, id: diva2:1271275
Forskningsfinansiär
Västerbottens läns landsting, Dnr ALFVLL-298001Vetenskapsrådet, Dnr 521-2013-2708Vetenskapsrådet, 2016-01891Hjärt-Lungfonden, Dnr 20150369Hjärt-Lungfonden, 20170481Tillgänglig från: 2018-12-17 Skapad: 2018-12-17 Senast uppdaterad: 2019-02-22Bibliografiskt granskad

Open Access i DiVA

Fulltext saknas i DiVA

Övriga länkar

Förlagets fulltextPubMed

Personposter BETA

Näslund, UlfNg, NawiLundgren, AnnaFhärm, EvaGrönlund, ChristerJohansson, HeleneLindahl, BerntLindvall, KristinaNilsson, Stefan K.Nordin, MariaNordin, StevenNyman, EmmaRocklöv, JoacimVanoli, DavideWeinehall, LarsWennberg, PatrikWester, PerNorberg, Margareta

Sök vidare i DiVA

Av författaren/redaktören
Näslund, UlfNg, NawiLundgren, AnnaFhärm, EvaGrönlund, ChristerJohansson, HeleneLindahl, BerntLindvall, KristinaNilsson, Stefan K.Nordin, MariaNordin, StevenNyman, EmmaRocklöv, JoacimVanoli, DavideWeinehall, LarsWennberg, PatrikWester, PerNorberg, Margareta
Av organisationen
Institutionen för folkhälsa och klinisk medicinEpidemiologi och global hälsaAllmänmedicinInstitutionen för strålningsvetenskaperYrkes- och miljömedicinFysiologisk kemiInstitutionen för psykologiMedicin
I samma tidskrift
The Lancet
Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologiKardiologi

Sök vidare utanför DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetricpoäng

doi
pubmed
urn-nbn
Totalt: 343 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf