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Phosphoproteome and gene expression profiling of ALK inhibition in neuroblastoma cell lines reveals conserved oncogenic pathways
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2018 (English)In: Science Signaling, ISSN 1945-0877, E-ISSN 1937-9145, Vol. 11, no 557, article id eaar5680Article in journal (Refereed) Published
Abstract [en]

Neuroblastoma is a common pediatric solid tumor that is often driven by oncogenic mutations or rearrangements of the gene encoding the tyrosine kinase receptor ALK. In relapsed neuroblastoma, the frequency of ALK mutation is increased, highlighting the importance of understanding ALK signaling in this cancer. Two papers identify alternative targets in ALK-driven neuroblastoma cells. By combining various proteomics analyses with protein-protein interaction networks, Emdal et al. found that IRS2, an adaptor protein in the insulin receptor signaling pathway, linked ALK signaling to neuroblastoma cell survival. Van den Eynden et al. integrated proteomics and gene expression analyses to identify ETS family transcription factors and the MAPK phosphatase DUSP4 as targets of ALK signaling. These papers identify new targets that could be exploited to treat ALK-positive neuroblastoma.

Place, publisher, year, edition, pages
American Association for the Advancement of Science , 2018. Vol. 11, no 557, article id eaar5680
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Cell and Molecular Biology
Identifiers
URN: urn:nbn:se:umu:diva-154048DOI: 10.1126/scisignal.aar5680ISI: 000451217900004PubMedID: 30459281OAI: oai:DiVA.org:umu-154048DiVA, id: diva2:1272597
Funder
Swedish Cancer Society, BH CAN15/775Swedish Cancer Society, RHP CAN15/391Swedish Cancer Society, EL CAN15/541Swedish Childhood Cancer Foundation, BH 2015-80Swedish Childhood Cancer Foundation, BH 2014-150Swedish Childhood Cancer Foundation, RHP 2015-96Swedish Childhood Cancer Foundation, JG TJ2016-0088Swedish Childhood Cancer Foundation, PR2016-2011Swedish Research Council, RHP 2015-04466Swedish Research Council, BH 2017-01324Swedish Research Council, EL 14-3596Swedish Foundation for Strategic Research , RB13-0204Göran Gustafsson Foundation for Research in Natural Sciences and MedicineKnut and Alice Wallenberg Foundation, KAW 2015.0144EU, Horizon 2020, 675712Available from: 2018-12-19 Created: 2018-12-19 Last updated: 2018-12-19Bibliographically approved

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Ruuth, Kristina

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