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Insulin-dependent diabetes: a chronic complication to acute pancreatitis in childhood acute lymphoblastic leukemia
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2019 (English)In: Pediatric Blood & Cancer, ISSN 1545-5009, E-ISSN 1545-5017, Vol. 66, no 1, article id e27437Article in journal (Refereed) Published
Abstract [en]

Pancreatitis is a frequent toxicity to acute lymphoblastic leukemia (ALL) treatment, significantly associated with asparaginase use, and may be followed by severe complications such as acute hyperglycaemia, need for mechanical ventilation, pseudocysts, and death. Here, we provide novel data on seven patients diagnosed with diabetes after pancreatitis and still requiring insulin treatment after a median follow-up of 4.2 years (range: 1.7-9.2). We describe the clinical course of pancreatitis and illustrate the association between pancreatic pseudocysts, older age, and development of insulin-dependent diabetes. Together, this study documents the persisting burden of pancreatitis in childhood ALL and underlines the need for plasma glucose level monitoring.

Place, publisher, year, edition, pages
Wiley-Blackwell, 2019. Vol. 66, no 1, article id e27437
Keywords [en]
acute lymphoblastic leukemia, diabetes, pancreatitis, toxicity
National Category
Pediatrics Gastroenterology and Hepatology
Identifiers
URN: urn:nbn:se:umu:diva-154024DOI: 10.1002/pbc.27437ISI: 000450821000024PubMedID: 30216644OAI: oai:DiVA.org:umu-154024DiVA, id: diva2:1273029
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Novo NordiskAvailable from: 2018-12-20 Created: 2018-12-20 Last updated: 2018-12-20Bibliographically approved

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Norén-Nyström, Ulrika

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