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Metabolic effects of an aspartate aminotransferase-inhibitor on two T-cell lines
Umeå University, Faculty of Science and Technology, Department of Chemistry.
Umeå University, Faculty of Science and Technology, Department of Chemistry.
2018 (English)In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 13, no 12, article id e0208025Article in journal (Refereed) Published
Abstract [en]

An emerging method to help elucidate the mode of action of experimental drugs is to use untargeted metabolomics of cell-systems. The interpretations of such screens are however complex and more examples with inhibitors of known targets are needed. Here two T-cell lines were treated with an inhibitor of aspartate aminotransferase and analyzed with untargeted GC-MS. The interpretation of the data was enhanced by the use of two different cell-lines and supports aspartate aminotransferase as a target. In addition, the data suggest an unexpected off-target effect on glutamate decarboxylase. The results exemplify the potency of metabolomics to provide insight into both mode of action and off-target effects of drug candidates.

Place, publisher, year, edition, pages
PUBLIC LIBRARY SCIENCE , 2018. Vol. 13, no 12, article id e0208025
National Category
Biochemistry and Molecular Biology
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URN: urn:nbn:se:umu:diva-154872DOI: 10.1371/journal.pone.0208025ISI: 000452640900007PubMedID: 30532126Scopus ID: 2-s2.0-85058105205OAI: oai:DiVA.org:umu-154872DiVA, id: diva2:1275148
Available from: 2019-01-04 Created: 2019-01-04 Last updated: 2019-01-04Bibliographically approved

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Antti, HenrikSellstedt, Magnus

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CiteExportLink to record
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  • apa
  • ieee
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  • de-DE
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