umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Dynamic contrast-enhanced magnetic resonance imaging may act as a biomarker for vascular damage in normal appearing brain tissue after radiotherapy in patients with glioblastoma
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Radiation Physics.
Show others and affiliations
2018 (English)In: Acta Radiologica Open, ISSN 2058-4601, Vol. 7, no 11, article id 2058460118808811Article in journal (Refereed) Published
Abstract [en]

Background

Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is a promising perfusion method and may be useful in evaluating radiation-induced changes in normal-appearing brain tissue.

Purpose

To assess whether radiotherapy induces changes in vascular permeability (Ktrans) and the fractional volume of the extravascular extracellular space (Ve) derived from DCE-MRI in normal-appearing brain tissue and possible relationships to radiation dose given.

Material and Methods

Seventeen patients with glioblastoma treated with radiotherapy and chemotherapy were included; five were excluded because of inconsistencies in the radiotherapy protocol or early drop-out. DCE-MRI, contrast-enhanced three-dimensional (3D) T1-weighted (T1W) images and T2-weighted fluid attenuated inversion recovery (T2-FLAIR) images were acquired before and on average 3.3, 30.6, 101.6, and 185.7 days after radiotherapy. Pre-radiotherapy CE T1W and T2-FLAIR images were segmented into white and gray matter, excluding all non-healthy tissue. Ktrans and Ve were calculated using the extended Kety model with the Parker population-based arterial input function. Six radiation dose regions were created for each tissue type, based on each patient’s computed tomography-based dose plan. Mean Ktrans and Ve were calculated over each dose region and tissue type.

Results

Global Ktrans and Ve demonstrated mostly non-significant changes with mean values higher for post-radiotherapy examinations in both gray and white matter compared to pre-radiotherapy. No relationship to radiation dose was found.

Conclusion

Additional studies are needed to validate if Ktrans and Ve derived from DCE-MRI may act as potential biomarkers for acute and early-delayed radiation-induced vascular damages. No dose-response relationship was found.

Place, publisher, year, edition, pages
Sage Publications, 2018. Vol. 7, no 11, article id 2058460118808811
Keywords [en]
Dynamic contrast-enhanced magnetic resonance imaging, DCE-MRI, radiation therapy/oncology, radiation effects, normal-appearing brain tissue, glioblastoma
National Category
Radiology, Nuclear Medicine and Medical Imaging
Identifiers
URN: urn:nbn:se:umu:diva-154961DOI: 10.1177/2058460118808811ISI: 000450106500001PubMedID: 30542625OAI: oai:DiVA.org:umu-154961DiVA, id: diva2:1275828
Available from: 2019-01-07 Created: 2019-01-07 Last updated: 2019-01-07Bibliographically approved

Open Access in DiVA

fulltext(799 kB)68 downloads
File information
File name FULLTEXT01.pdfFile size 799 kBChecksum SHA-512
bcbc0b7792853d48fbc62566676edb8ca1a6ffdf87be54153d1a6f2b4b98d53a33de2f905eda9ef0ccd18868408a2e1fad3dd69568a037b604f6d25bc7c381b3
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Authority records BETA

Nyholm, Tufve

Search in DiVA

By author/editor
Nyholm, Tufve
By organisation
Radiation Physics
Radiology, Nuclear Medicine and Medical Imaging

Search outside of DiVA

GoogleGoogle Scholar
Total: 68 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 113 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf