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Reference intervals for reticulocyte hemoglobin content in healthy infants
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Paediatrics.
2018 (English)In: Pediatric Research, ISSN 0031-3998, E-ISSN 1530-0447, Vol. 84, no 5, p. 657-661Article in journal (Refereed) Published
Abstract [en]

Objectives: Iron deficiency anemia in childhood is a serious public health problem worldwide. Reticulocyte hemoglobin content (Ret-He) is a novel biomarker of iron deficiency adopted for adults but there is a lack of reference intervals for Ret-He in infants. The aim of this study was to provide data from healthy infants.

Methods: Swedish infants (n = 456), born at term after normal pregnancies were included. Ret-He was measured at birth (umbilical cord sample), 48–72 h, 4 months, and 12 months. Reference intervals were calculated as ±2 standard deviations from the mean of Ret-He.

Results: Reference intervals for newborn Ret-He were 27.4 to 36.0 pg/L (N = 376) in the cord sample, 28.1–37.7 pg/L (N = 253) at 48–72 h, 25.6–33.4 pg/L (N = 341) at four months and 24.9–34.1 pg/L (N = 288) at 12 months. Ret-He was significantly lower among iron-deficient infants, at 4 months mean difference (95% CI) −4.2 pg/L (−6.1 to −2.4) and at 12 months mean difference (95% CI) −3.4 pg/L (−5.0 to −1.8).

Conclusions: This longitudinal study presents Ret-He reference intervals based on non-anemic and non-iron-deficient infants and constitutes a step towards standardizing Ret-He as a pre-anemia biomarker of iron deficiency in children.

Place, publisher, year, edition, pages
Nature Publishing Group, 2018. Vol. 84, no 5, p. 657-661
National Category
Pediatrics
Identifiers
URN: urn:nbn:se:umu:diva-155118DOI: 10.1038/s41390-018-0046-4ISI: 000453019100021PubMedID: 30140071OAI: oai:DiVA.org:umu-155118DiVA, id: diva2:1276634
Available from: 2019-01-08 Created: 2019-01-08 Last updated: 2019-02-20Bibliographically approved

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Domellöf, Magnus

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