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Overdiagnosis in the population-based organized breast cancer screening program estimated by a non-homogeneous multi-state model: a cohort study using individual data with long-term follow-up
Umeå universitet, Medicinska fakulteten, Institutionen för strålningsvetenskaper, Onkologi.ORCID-id: 0000-0002-6169-5155
Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Institutionen för matematik och matematisk statistik.
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2018 (Engelska)Ingår i: Breast Cancer Research, ISSN 1465-5411, E-ISSN 1465-542X, Vol. 20, artikel-id 153Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background: Overdiagnosis, defined as the detection of a cancer that would not become clinically apparent in a woman’s lifetime without screening, has become a growing concern. Similar underlying risk of breast cancer in the screened and control groups is a prerequisite for unbiased estimates of overdiagnosis, but a contemporary control group is usually not available in organized screening programs.

Methods: We estimated the frequency of overdiagnosis of breast cancer due to screening in women 50–69 years old by using individual screening data from the population-based organized screening program in Stockholm County 1989–2014. A hidden Markov model with four latent states and three observed states was constructed to estimate the natural progression of breast cancer and the test sensitivity. Piecewise transition rates were used to consider the time-varying transition rates. The expected number of detected non-progressive breast cancer cases was calculated.

Results: During the study period, 2,333,153 invitations were sent out; on average, the participation rate in the screening program was 72.7% and the average recall rate was 2.48%. In total, 14,648 invasive breast cancer cases were diagnosed; among the 8305 screen-detected cases, the expected number of non-progressive breast cancer cases was 35.9, which is equivalent to 0.43% (95% confidence interval (CI) 0.10%–2.2%) overdiagnosis. The corresponding estimates for the prevalent and subsequent rounds were 15.6 (0.87%, 95% CI 0.20%–4.3%) and 20.3 (0.31%, 95% CI 0.07%–1.6%), respectively. The likelihood ratio test showed that the non-homogeneous model fitted the data better than an age-homogeneous model (P<0.001).

Conclusions: Our findings suggest that overdiagnosis in the organized biennial mammographic screening for women 50–69 in Stockholm County is a minor phenomenon. The frequency of overdiagnosis in the prevalent screening round was higher than that in subsequent rounds. The non-homogeneous model performed better than the simpler, traditional homogeneous model.

Ort, förlag, år, upplaga, sidor
BioMed Central, 2018. Vol. 20, artikel-id 153
Nyckelord [en]
Overdiagnosis, Breast cancer, Organized screening program, Mammography, Multi-state model
Nationell ämneskategori
Cancer och onkologi
Identifikatorer
URN: urn:nbn:se:umu:diva-155103DOI: 10.1186/s13058-018-1082-zISI: 000453551900001PubMedID: 30558679OAI: oai:DiVA.org:umu-155103DiVA, id: diva2:1277267
Forskningsfinansiär
VetenskapsrådetVästerbottens läns landstingTillgänglig från: 2019-01-10 Skapad: 2019-01-10 Senast uppdaterad: 2019-01-10Bibliografiskt granskad

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Wu, Wendy Yi-YingLiu, XijiaNyström, LennarthJonsson, Håkan

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Wu, Wendy Yi-YingLiu, XijiaNyström, LennarthJonsson, Håkan
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OnkologiInstitutionen för matematik och matematisk statistikEpidemiologi och global hälsa
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