umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Copy number variation: A prognostic marker for young patients with squamous cell carcinoma of the oral tongue
Umeå University, Faculty of Medicine, Department of Medical Biosciences, Pathology.
Umeå University, Faculty of Medicine, Department of Medical Biosciences, Pathology.
Umeå University, Faculty of Medicine, Department of Medical Biosciences, Pathology.
Show others and affiliations
2019 (English)In: Journal of Oral Pathology & Medicine, ISSN 0904-2512, E-ISSN 1600-0714, Vol. 48, no 1, p. 24-30Article in journal (Refereed) Published
Abstract [en]

Background The incidence of squamous cell carcinoma of the oral tongue (SCCOT) is increasing in people under age 40. There is an urgent need to identify prognostic markers that help identify young SCCOT patients with poor prognosis in order to select these for individualized treatment. Materials and methods To identify genetic markers that can serve as prognostic markers for young SCCOT patients, we first investigated four young (<= 40 years) and five elderly patients (>= 50 years) using global RNA sequencing and whole-exome sequencing. Next, we combined our data with data on SCCOT from the cancer genome atlas (TCGA), giving a total of 16 young and 104 elderly, to explore the correlations between genomic variations and clinical outcomes. Results In agreement with previous studies, we found that SCCOT from young and elderly patients was transcriptomically and also genomically similar with no significant differences regarding cancer driver genes, germline predisposition genes, or the burden of somatic single nucleotide variations (SNVs). However, a disparate copy number variation (CNV) was found in young patients with distinct clinical outcome. Combined with data from TCGA, we found that the overall survival was significantly better in young patients with low-CNV (n = 5) compared to high-CNV (n = 11) burden (P = 0.044). Conclusions Copy number variation burden is a useful single prognostic marker for SCCOT from young, but not elderly, patients. CNV burden thus holds promise to form an important contribution when selecting suitable treatment protocols for young patients with SCCOT.

Place, publisher, year, edition, pages
John Wiley & Sons, 2019. Vol. 48, no 1, p. 24-30
Keywords [en]
age, copy number variation, prognosis, squamous cell carcinoma of the oral tongue, whole-exome sequencing
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:umu:diva-155648DOI: 10.1111/jop.12792ISI: 000454799800005PubMedID: 30357923OAI: oai:DiVA.org:umu-155648DiVA, id: diva2:1282612
Funder
Swedish Cancer Society, 17 0663Västerbotten County CouncilAvailable from: 2019-01-25 Created: 2019-01-25 Last updated: 2019-01-25Bibliographically approved

Open Access in DiVA

fulltext(709 kB)100 downloads
File information
File name FULLTEXT01.pdfFile size 709 kBChecksum SHA-512
4609aecc367c23a001a161ccc75c394c1b3e0abc7c783bf3aa3ab8d21772cb99296ce8951df8dbf0075c17c3f4e42a6eafccf9d48d5f952fdc35ba364a67617a
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Authority records BETA

Gu, XiaolianBoldrup, LindaWang, LixiaoFåhraeus, RobinNorberg-Spaak, LenaSgaramella, NicolaWilms, TorbenNylander, Karin

Search in DiVA

By author/editor
Gu, XiaolianBoldrup, LindaWang, LixiaoFåhraeus, RobinNorberg-Spaak, LenaSgaramella, NicolaWilms, TorbenNylander, Karin
By organisation
PathologyDepartment of Medical BiosciencesOtorhinolaryngology
In the same journal
Journal of Oral Pathology & Medicine
Cancer and Oncology

Search outside of DiVA

GoogleGoogle Scholar
Total: 100 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 224 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf