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Postnatal nutritional intakes and hyperglycemia as determinants of blood pressure at 6.5 years of age in children born extremely preterm
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Paediatrics.
Umeå University, Faculty of Social Sciences, Department of Food and Nutrition.ORCID iD: 0000-0002-4649-0653
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2019 (English)In: Pediatric Research, ISSN 0031-3998, E-ISSN 1530-0447, Vol. 86, no 1, p. 115-121Article in journal (Refereed) Published
Abstract [en]

Background: Adverse developmental programming by early-life exposures might account for higher blood pressure (BP) in children born extremely preterm. We assessed associations between nutrition, growth and hyperglycemia early in infancy, and BP at 6.5 years of age in children born extremely preterm.

Methods: Data regarding perinatal exposures including nutrition, growth and glycemia status were collected from the Extremely Preterm Infants in Sweden Study (EXPRESS), a population-based cohort including infants born <27 gestational weeks during 2004–2007. BP measurements were performed at 6.5 years of age in a sub-cohort of 171 children (35% of the surviving children).

Results: Higher mean daily protein intake (+1 g/kg/day) during postnatal weeks 1–8 was associated with 0.40 (±0.18) SD higher diastolic BP. Higher mean daily carbohydrate intake (+1 g/kg/day) during the same period was associated with 0.18 (±0.05) and 0.14 (±0.04) SD higher systolic and diastolic BP, respectively. No associations were found between infant growth (weight, length) and later BP. Hyperglycemia and its duration during postnatal weeks 1–4 were associated primarily with higher diastolic BP z-scores.

Conclusions: These findings emphasize the importance of modifiable early-life exposures, such as nutrition and hyperglycemia, in determining long-term outcomes in children born extremely preterm.

Place, publisher, year, edition, pages
Nature Publishing Group, 2019. Vol. 86, no 1, p. 115-121
National Category
Pediatrics
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URN: urn:nbn:se:umu:diva-155795DOI: 10.1038/s41390-019-0341-8ISI: 000472723400021PubMedID: 30776793OAI: oai:DiVA.org:umu-155795DiVA, id: diva2:1283024
Funder
Swedish Research Council, 2016-02095Swedish Heart Lung Foundation, 20090380Swedish Heart Lung Foundation, 20100457Västerbotten County CouncilStockholm County CouncilRegion SkåneAvailable from: 2019-01-28 Created: 2019-01-28 Last updated: 2019-07-25Bibliographically approved

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Zamir, ItayDomellöf, Magnus

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Zamir, ItayStoltz Sjöström, ElisabethDomellöf, Magnus
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