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Neutrophil extracellular traps in fungal infection
Umeå University, Faculty of Medicine, Department of Clinical Microbiology. Umeå University, Faculty of Medicine, Umeå Centre for Microbial Research (UCMR). Umeå University, Faculty of Medicine, Molecular Infection Medicine Sweden (MIMS). (Constantin Urban)ORCID iD: 0000-0003-1438-1134
2019 (English)In: Seminars in Cell and Developmental Biology, ISSN 1084-9521, E-ISSN 1096-3634, Vol. 89, p. 47-57Article in journal (Refereed) Published
Abstract [en]

Fungal infections are a continuously increasing problem in modern health care. Understanding the complex biology of the emerging pathogens and unraveling the mechanisms of host defense may form the basis for the development of more efficient diagnostic and therapeutic tools. Neutrophils play a pivotal role in the defense against fungal pathogens. These phagocytic hunters migrate towards invading fungal microorganisms and eradicate them by phagocytosis, oxidative burst and release of neutrophil extracellular traps (NETs). In the last decade, the process of NET formation has received unparalleled attention, with numerous studies revealing the relevance of this neutrophil function for control of various mycoses. Here, we describe NET formation and summarize its role as part of the innate immune defense against fungal pathogens. We highlight factors influencing the formation of these structures and molecular mechanisms employed by fungi to impair the formation of NETs or subvert their antifungal effects.

Place, publisher, year, edition, pages
Elsevier, 2019. Vol. 89, p. 47-57
Keywords [en]
Aspergillus, Candida, Immunology, Neutrophil, Neutrophil extracellular trap (NET)
National Category
Microbiology in the medical area
Research subject
Infectious Diseases; Immunology
Identifiers
URN: urn:nbn:se:umu:diva-156197DOI: 10.1016/j.semcdb.2018.03.020ISI: 000463473400006PubMedID: 29601861OAI: oai:DiVA.org:umu-156197DiVA, id: diva2:1286583
Funder
Swedish Research Council, VR-MH 2014-02281The Kempe Foundations, SMK1453NIH (National Institute of Health), K08 AI108727Available from: 2019-02-07 Created: 2019-02-07 Last updated: 2019-04-26Bibliographically approved

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Urban, Constantin F.

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Department of Clinical MicrobiologyUmeå Centre for Microbial Research (UCMR)Molecular Infection Medicine Sweden (MIMS)
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