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Consumption of whole grain/bran rye instead of refined wheat decrease concentrations of TNF-R2, e-selectin, and endostatin in an exploratory study in men with prostate cancer
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Nutritional Research.ORCID iD: 0000-0001-9581-3845
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2019 (English)In: Clinical Nutrition, ISSN 0261-5614, E-ISSN 1532-1983, article id S0261-5614(19)30009-3Article in journal (Refereed) Epub ahead of print
Abstract [en]

BACKGROUND & AIMS: Rye consumption has shown beneficial effects on prostate cancer tumors, as indicated by slower initial tumor growth in animal models and lowering of prostate-specific antigen (PSA) in humans. This study evaluated the effects of whole grain/bran rye consumption on low-grade inflammation and endothelial function biomarkers in men with prostate cancer.

METHODS: Seventeen men with untreated, low-grade prostate cancer consumed 485 g rye whole grain and bran products (RP) per day or refined wheat products with added cellulose (WP) in a randomized crossover design. Fasting blood samples were taken before and after 2, 4, and 6 weeks of treatment.

RESULTS: Concentrations of tumor nuclear factor-receptor 2 (TNF-R2), e-selectin, and endostatin were significantly lower after consumption of the RP diet compared with WP (p < 0.05). Cathepsin S concentration was positively correlated to TNF-R2 and endostatin concentrations across all occasions. Strong correlations were consistently found between intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) and between interleukin-6 (IL-6) and interleukin-1 receptor antagonist (IL-1RA). No effect of intervention was found in 92 inflammation-related protein biomarkers measured in a proximity extension assay.

CONCLUSIONS: RP diet lowered TNF-R2, e-selectin, and endostatin, compared with WP in men with prostate cancer. These effects were accompanied by a reduction in PSA.

Place, publisher, year, edition, pages
Elsevier, 2019. article id S0261-5614(19)30009-3
Keywords [en]
Endothelial function markers, Low-grade inflammatory markers, Plasma, Prostate cancer, Refined wheat, Whole grain/bran rye
National Category
Nutrition and Dietetics
Identifiers
URN: urn:nbn:se:umu:diva-156369DOI: 10.1016/j.clnu.2019.01.007PubMedID: 30685298OAI: oai:DiVA.org:umu-156369DiVA, id: diva2:1288333
Available from: 2019-02-13 Created: 2019-02-13 Last updated: 2019-02-27

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Hallmans, GöranLandberg, Rikard

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