umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Profiling and activity screening of Dammarane-type triterpen saponins from Gynostemma pentaphyllum with glucose-dependent insulin secretory activity
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine. Department of Molecular Sciences, Swedish University of Agricultural Sciences, Uppsala, Sweden.
Show others and affiliations
2019 (English)In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 9, article id 627Article in journal (Refereed) Published
Abstract [en]

The global prevalence of type 2 diabetes is increasing rapidly; consequently there is great need for new and novel therapeutic options. Gynostemma pentaphyllum (GP) is a traditional medicinal plant, mainly present in Southeast Asian countries, that has been reported to exert antidiabetic effects, by stimulating insulin secretion. The specific compound responsible for this effect is however as yet unidentified. Screening for discovery and identification of bioactive compounds of an herbal GP extract, was performed in isolated pancreatic islets from spontaneously diabetic Goto-Kakizaki (GK) rats, a model of type 2 diabetes, and from non-diabetic control Wistar rats. From this herbal extract 27 dammarane-type saponins, including two novel compounds, were isolated and their structure was elucidated by mass spectrometry and NMR spectroscopy. One of the dammarane-type triterpenoid showed a glucose-dependent insulin secretion activity. This compound, gylongiposide I, displays unique abilities to stimulate insulin release at high glucose levels (16.7 mM), but limited effects at a low glucose concentration (3.3 mM). Further studies on this compound, also in vivo, are warranted with the aim of developing a novel anti-diabetic therapeutic with glucose-dependent insulinogenic effect.

Place, publisher, year, edition, pages
Nature Publishing Group, 2019. Vol. 9, article id 627
National Category
Endocrinology and Diabetes
Identifiers
URN: urn:nbn:se:umu:diva-156310DOI: 10.1038/s41598-018-37517-3ISI: 000456554600066PubMedID: 30679754OAI: oai:DiVA.org:umu-156310DiVA, id: diva2:1290698
Available from: 2019-02-21 Created: 2019-02-21 Last updated: 2019-02-21Bibliographically approved

Open Access in DiVA

fulltext(3418 kB)46 downloads
File information
File name FULLTEXT01.pdfFile size 3418 kBChecksum SHA-512
89ec520fa76dba7bdb4bbe15c00ddd1382b2062cd9f528a518877f16e954d36158002199c907041d85ad0d0732f73683ebb0879987ddb978991387fba7ba7c14
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Authority records BETA

Ehtesham, Emad

Search in DiVA

By author/editor
Ehtesham, Emad
By organisation
Department of Public Health and Clinical Medicine
In the same journal
Scientific Reports
Endocrinology and Diabetes

Search outside of DiVA

GoogleGoogle Scholar
Total: 46 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 87 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf