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Malleus fracture healing studied in a new sheep model
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Otorhinolaryngology.
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Otorhinolaryngology.
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(English)Manuscript (preprint) (Other academic)
Keywords [en]
malleus fracture bone remodeling sheep
National Category
Otorhinolaryngology
Research subject
Oto-Rhino-Laryngology
Identifiers
URN: urn:nbn:se:umu:diva-156850OAI: oai:DiVA.org:umu-156850DiVA, id: diva2:1292843
Available from: 2019-03-01 Created: 2019-03-01 Last updated: 2019-03-19
In thesis
1. Malleus fracture: experimental and clinical aspects
Open this publication in new window or tab >>Malleus fracture: experimental and clinical aspects
2019 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Background: Patients with malleus fractures are described as rare in the literature. The cause of these fractures are most commonly trauma and digital manipulation of the ear canal, while in some cases the causes are unknown. At our clinic we record one new case every year, which leads to an incidence of approximately 40-50 new cases every year in Sweden. Different treatments have been proposed for this condition. However, since the condition is rare, no consensus has been reached regarding the best treatment. Additionally, it remains unclear whether malleus fractures can heal.

Aim: To get a deeper understanding of how malleus fractures occur, how they should be treated surgically, and if the malleus shows any sign of bone healing.

Materials and methods: Paper I. We carried out both a retrospective study of the medical records of nine Swedish patients with isolated malleus fractures, and a literature review of this condition. Symptoms, clinical findings and patients’ history were collected.Paper II. Ossiculoplasty on human temporal bones was performed in the presence of a malleus fracture. We developed a surgical model from freshly frozen human temporal bones, and we performed Laser Doppler vibrometry (LDV) measurements on this model both before and after ossiculoplasty.Paper III. We performed ossiculoplasties with different types of partial ossicular replacement prostheses (PORP) on human temporal bones and we measured the results with LDV.Paper IV. We performed an in vivo animal study on Merino sheep, in which we produced isolated malleus fractures. We then compared the bone healing of these fractures with that of the nasal bone and the mandible. Bone healing was detected with micro-CT.

Results: Paper I. The most common cause of isolated malleus fractures was found to be a so-called “digital” trauma, which occurred when the patients had removed a finger from the wet ear canal after bath. The hearing loss was occasionally accompanied by tinnitus and transient pain. Pneumatic otoscopy and tympanometry showed a hypermobile tympanic membrane, while audiometry showed a conductive hearing loss that increased towards higher frequencies.Paper II. Our LDV measurements indicated that fixation of an isolated malleus with bone cement may give the best results after surgery.Paper III. The best LDV measurements were obtained when ossiculoplasty was done using a PORP in lateral contact with both the tympanic membrane and the malleus handle.Paper IV. In our animal study we found no signs of bone healing at micro-CT four weeks after producing the malleus fractures. In contrast, both the nasal bone and the mandible showed bone healing. This indicates that the bone healing properties of the ossicles probably differ from those of other bones in the body.

Conclusion: Digital trauma is the major cause of isolated malleus fractures. Pneumatic otoscopy and tympanometry showed a hypermobile tympanic membrane, while audiometry showed a conductive hearing loss increasing towards the higher frequencies. We developed a method to employ freshly frozen human temporal bones and we used LDV for detecting optimal results. This method allows to evaluate and develop otosurgery, aimed to restore hearing after an interrupted ossicular chain. The animal study indicates that malleus fractures will not heal spontaneously.

Place, publisher, year, edition, pages
Umeå: Umeå universitet, 2019. p. 52
Series
Umeå University medical dissertations, ISSN 0346-6612 ; 2013
Keywords
malleus fracture middle ear human temporal bone laser doppler vibrometry
National Category
Otorhinolaryngology
Research subject
Oto-Rhino-Laryngology
Identifiers
urn:nbn:se:umu:diva-156847 (URN)978-91-7855-021-0 (ISBN)
Public defence
2019-03-29, Aulan, Sunderby sjukhus, Luleå, 09:00 (Swedish)
Opponent
Supervisors
Available from: 2019-03-08 Created: 2019-03-01 Last updated: 2019-03-21Bibliographically approved

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Niklasson, AndersTano, Krister

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