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Type III secretion system
Inserm U768 and Institut Pasteur, Unité de Pathogénie Microbienne Moléculaire, 75724 Paris Cedex 15, France..ORCID iD: 0000-0002-9915-002x
Inserm U768 and Institut Pasteur, Unité de Pathogénie Microbienne Moléculaire, 75724 Paris Cedex 15, France.
2014 (English)In: Current Biology, ISSN 0960-9822, E-ISSN 1879-0445, Vol. 24, no 17, p. R784-R791Article in journal (Refereed) Published
Abstract [en]

The type III secretion system (T3SS) is a membrane-embedded nanomachine found in several Gram-negative bacteria. Upon contact between bacteria and host cells, the syringe-like T3SS (Figure 1) transfers proteins termed effectors from the bacterial cytosol to the cytoplasm or the plasma membrane of a single target cell. This is a major difference from secretion systems that merely release molecules into the extracellular milieu, where they act on potentially distant target cells expressing the relevant surface receptors. The syringe architecture is conserved at the structural and functional level and supports injection into a great variety of hosts and tissues. However, the pool of effectors is species specific and determines the outcome of the interaction, via modulation of target-cell function.

Place, publisher, year, edition, pages
2014. Vol. 24, no 17, p. R784-R791
National Category
Microbiology
Identifiers
URN: urn:nbn:se:umu:diva-156942DOI: 10.1016/j.cub.2014.07.016PubMedID: 25202865OAI: oai:DiVA.org:umu-156942DiVA, id: diva2:1293118
Available from: 2019-03-03 Created: 2019-03-03 Last updated: 2019-03-08Bibliographically approved

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Puhar, Andrea

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