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Reducing the stigma of long acting injectable antipsychotics: current concepts and future developments
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Psychiatry.
2018 (English)In: Nordic Journal of Psychiatry, ISSN 0803-9488, E-ISSN 1502-4725, Vol. 72, p. S36-S39Article in journal (Refereed) Published
Abstract [en]

Background: Long acting injectable antipsychotics (LAI-APs) are considered a major advance in psychiatric treatment concerning treatment adherence and outcomes. Yet, both, doctors and patients remain sceptical.

Aim: To explain the rationale for using LAI-APs, review their effectiveness and explore barriers to use.

Method: Clinical overview of LAI-APs from the patient and doctor's perspective.

Results: LAI-APs were developed to increase adherence to treatment, thereby improving treatment outcomes. LAI-APs may reduce the risk of relapse and hospitalisation. Yet, the evidence from the few meta-analyses available remains weak. Both patients and doctors may associate LAI-APs with stigma and coercion. Current means of improving adherence include more focus on the therapeutic relationship, better information, adverse effects minimisation and half-life extension of LAI-APs. Future means of improving adherence include novel administration techniques that abolish the need for injection.

Conclusions: For both, clinicians and drug developers, drug adherence remains a major target for improving treatment outcomes.

Place, publisher, year, edition, pages
Taylor & Francis, 2018. Vol. 72, p. S36-S39
Keywords [en]
Antipsychotics, long-acting injections, adherence, relapse, blood-brain-barrier
National Category
Psychiatry
Identifiers
URN: urn:nbn:se:umu:diva-156907DOI: 10.1080/08039488.2018.1525638ISI: 000458264000012PubMedID: 30688170OAI: oai:DiVA.org:umu-156907DiVA, id: diva2:1295054
Conference
4th Conference on Masterclass Psychiatry - Transcultural Psychiatry - Diagnostics and Treatment, FEB 22-23, 2018, Luleå, Sweden
Note

Supplement 1

Available from: 2019-03-09 Created: 2019-03-09 Last updated: 2019-03-19Bibliographically approved

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Werneke, Ursula

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