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Reference values of left atrial size and function according to age: should we redefine the normal upper limits?
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2019 (English)In: International Journal of Cardiac Imaging, ISSN 1569-5794, E-ISSN 1875-8312, Vol. 35, no 1, p. 41-48Article in journal (Refereed) Published
Abstract [en]

Different cut-offs have been proposed for left atrial (LA) size. Furthermore, conflicting results have been reported about the influence of age on LA size and data on the impact of age on LA myocardial function are scanty. The aim of this study was to derive references values for LA size and function in healthy subjects and to evaluate the impact of age. We conducted a systematic literature search of MEDLINE database. We included only studies evaluating healthy subjects, with age ranged between 18 and 80years. Parameters were compared among four age groups, <30, 30-45, >45-60, >60years. Three hundred twenty-six studies met the inclusion criteria and the final population consisted of 62,821 subjects. LA volume index (LAVi) did not differ among different age groups (p=0.21). The normal upper limit of LAVi was 24mL/m(2). LA reservoir function, measured by strain, did not differ among age groups (38 +/- 3%, 32-43%; p=0.74). Left ventricular (LV) size and function were not different among groups, except LV mass index. A decrease in E/A ratio and an increase in E/e ratio were found with advancing age (p<0.0001 and p=0.001, respectively). In healthy subjects the normal upper limit of LAVi was lower than that recommended and is not influenced by advancing age. Furthermore, also LA function measured by strain was not affected by age. The current reference values of LAVi should be used with caution when applied to healthy subjects.

Place, publisher, year, edition, pages
Springer, 2019. Vol. 35, no 1, p. 41-48
Keywords [en]
Echocardiography, Advanced cardiac imaging, Meta-analysis, Strain, Systematic review
National Category
Cardiac and Cardiovascular Systems
Identifiers
URN: urn:nbn:se:umu:diva-156899DOI: 10.1007/s10554-018-1427-9ISI: 000458270500005PubMedID: 30076516OAI: oai:DiVA.org:umu-156899DiVA, id: diva2:1295059
Available from: 2019-03-09 Created: 2019-03-09 Last updated: 2019-03-09Bibliographically approved

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Henein, Michael

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D'Ascenzi, FlavioMondillo, SergioHenein, Michael
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